Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4724418..4724985 Replicon chromosome
Accession NZ_LR134195
Organism Raoultella ornithinolytica strain NCTC13096

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag EL106_RS22400 Protein ID WP_126509934.1
Coordinates 4724710..4724985 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag EL106_RS22395 Protein ID WP_075808907.1
Coordinates 4724418..4724723 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL106_RS22370 4719625..4720689 - 1065 WP_004857527.1 DUF2955 domain-containing protein -
EL106_RS22375 4720679..4721746 - 1068 WP_004857525.1 HlyD family secretion protein -
EL106_RS22380 4721753..4722217 - 465 WP_004857523.1 MarR family transcriptional regulator -
EL106_RS22385 4722508..4722672 - 165 WP_004857521.1 DUF1127 domain-containing protein -
EL106_RS22390 4722850..4724262 + 1413 WP_015585221.1 PLP-dependent aminotransferase family protein -
EL106_RS22395 4724418..4724723 - 306 WP_075808907.1 BrnA antitoxin family protein Antitoxin
EL106_RS22400 4724710..4724985 - 276 WP_126509934.1 BrnT family toxin Toxin
EL106_RS22405 4725102..4725521 - 420 WP_099842693.1 FosA family fosfomycin resistance glutathione transferase -
EL106_RS22410 4725515..4726423 - 909 WP_126509935.1 LysR family transcriptional regulator -
EL106_RS22415 4726511..4727293 + 783 WP_126509936.1 NAD(P)H-dependent oxidoreductase -
EL106_RS22420 4727441..4728019 + 579 WP_004857495.1 TetR/AcrR family transcriptional regulator -
EL106_RS22425 4728163..4728975 + 813 WP_004857492.1 winged helix-turn-helix domain-containing protein -
EL106_RS22430 4728972..4729490 + 519 WP_015585229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-87)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-93)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10602.96 Da        Isoelectric Point: 6.7600

>T287001 WP_126509934.1 NZ_LR134195:c4724985-4724710 [Raoultella ornithinolytica]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRHERYENGEYRWQTIGLVHGVIVVLVAHSIRFESGTEVIRIIS
ARKADKNYEHG

Download         Length: 276 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11611.17 Da        Isoelectric Point: 9.7962

>AT287001 WP_075808907.1 NZ_LR134195:c4724723-4724418 [Raoultella ornithinolytica]
MSMVKHKRDNPTALTAQREDELKALAKKSDDDIDYSDIPSSDDGLWSDAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKKS

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References