Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4158378..4158997 Replicon chromosome
Accession NZ_LR134195
Organism Raoultella ornithinolytica strain NCTC13096

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag EL106_RS19680 Protein ID WP_004858783.1
Coordinates 4158779..4158997 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag EL106_RS19675 Protein ID WP_004858785.1
Coordinates 4158378..4158752 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL106_RS19665 4153488..4154681 + 1194 WP_004858789.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL106_RS19670 4154704..4157850 + 3147 WP_004858787.1 multidrug efflux RND transporter permease subunit -
EL106_RS19675 4158378..4158752 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
EL106_RS19680 4158779..4158997 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
EL106_RS19685 4159149..4159715 + 567 WP_004858781.1 maltose O-acetyltransferase -
EL106_RS19690 4159815..4160285 + 471 WP_004858780.1 YlaC family protein -
EL106_RS19695 4160260..4161711 - 1452 WP_126509892.1 PLP-dependent aminotransferase family protein -
EL106_RS19700 4161815..4162525 + 711 WP_015585015.1 GNAT family N-acetyltransferase -
EL106_RS19705 4162522..4162662 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL106_RS19710 4162665..4162925 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T287000 WP_004858783.1 NZ_LR134195:4158779-4158997 [Raoultella ornithinolytica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT287000 WP_004858785.1 NZ_LR134195:4158378-4158752 [Raoultella ornithinolytica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References