Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2744345..2745948 Replicon chromosome
Accession NZ_LR134195
Organism Raoultella ornithinolytica strain NCTC13096

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag EL106_RS12995 Protein ID WP_015584335.1
Coordinates 2744345..2745676 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag EL106_RS13000 Protein ID WP_032717448.1
Coordinates 2745676..2745948 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL106_RS12980 2740219..2741133 - 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -
EL106_RS12985 2741233..2742291 - 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
EL106_RS12990 2742997..2744412 + 1416 WP_099144431.1 glycoside hydrolase family 10 protein -
EL106_RS12995 2744345..2745676 - 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
EL106_RS13000 2745676..2745948 - 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL106_RS13005 2746151..2746705 - 555 WP_004861926.1 RNA polymerase sigma factor -
EL106_RS13010 2746711..2747136 - 426 WP_032724724.1 hypothetical protein -
EL106_RS13015 2747268..2748221 - 954 WP_004861921.1 hypothetical protein -
EL106_RS13020 2748435..2749067 - 633 WP_069475943.1 class I SAM-dependent methyltransferase -
EL106_RS13025 2749087..2750328 - 1242 WP_004861912.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T286999 WP_015584335.1 NZ_LR134195:c2745676-2744345 [Raoultella ornithinolytica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT286999 WP_032717448.1 NZ_LR134195:c2745948-2745676 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References