Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 67101..67648 Replicon chromosome
Accession NZ_LR134195
Organism Raoultella ornithinolytica strain NCTC13096

Toxin (Protein)


Gene name ccdB Uniprot ID A0A808XUV0
Locus tag EL106_RS00315 Protein ID WP_048025274.1
Coordinates 67101..67409 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag EL106_RS00320 Protein ID WP_126509333.1
Coordinates 67412..67648 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL106_RS00285 62280..62582 - 303 WP_015585486.1 PTS lactose/cellobiose transporter subunit IIA -
EL106_RS00290 62717..64042 - 1326 WP_126509332.1 PTS sugar transporter subunit IIC -
EL106_RS00295 64054..64368 - 315 WP_004869063.1 PTS sugar transporter subunit IIB -
EL106_RS00300 64663..65604 + 942 WP_015585487.1 LacI family transcriptional regulator -
EL106_RS00305 65699..65974 - 276 WP_162769256.1 hypothetical protein -
EL106_RS00310 66083..66985 - 903 WP_015585496.1 EamA family transporter -
EL106_RS00315 67101..67409 - 309 WP_048025274.1 CcdB family protein Toxin
EL106_RS00320 67412..67648 - 237 WP_126509333.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EL106_RS00325 67754..69187 - 1434 WP_069476354.1 PTS N-acetylmuramic acid transporter subunit IIBC -
EL106_RS00330 69212..70114 - 903 WP_088402359.1 N-acetylmuramic acid 6-phosphate etherase -
EL106_RS00335 70279..71442 - 1164 WP_004869055.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11778.62 Da        Isoelectric Point: 6.7156

>T286991 WP_048025274.1 NZ_LR134195:c67409-67101 [Raoultella ornithinolytica]
IQYYVYKNTGRITVYPYLLDVQSDIIGMRNTRVVIPLFPLRNYKGPRADRLTPVVTVEGEEYVVMTHELASIPQRVLGEE
VCHLNHQREVVKASIDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8928.11 Da        Isoelectric Point: 5.6579

>AT286991 WP_126509333.1 NZ_LR134195:c67648-67412 [Raoultella ornithinolytica]
MPAVKHNKQNVSVTLDPILVKQAREIGINLSQTLTSALKSEIHSIEMTRWQKENARAIDYLNDLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XUV0

Antitoxin

Source ID Structure

References