Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2170320..2170834 Replicon chromosome
Accession NZ_LR134193
Organism Staphylococcus aureus strain NCTC13616

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag EL036_RS11130 Protein ID WP_000581792.1
Coordinates 2170320..2170529 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag EL036_RS11135 Protein ID WP_000138928.1
Coordinates 2170541..2170834 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL036_RS11110 2165828..2167186 - 1359 WP_000611469.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EL036_RS11115 2167201..2168271 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
EL036_RS11120 2168589..2169791 + 1203 WP_001109944.1 rod shape-determining protein RodA -
EL036_RS11125 2170055..2170192 - 138 WP_000828354.1 hypothetical protein -
EL036_RS11130 2170320..2170529 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
EL036_RS11135 2170541..2170834 - 294 WP_000138928.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL036_RS11140 2171000..2172484 + 1485 WP_000571551.1 cardiolipin synthase -
EL036_RS11145 2172512..2173159 + 648 WP_001187617.1 HD domain-containing protein -
EL036_RS11155 2173637..2174509 - 873 WP_000725802.1 membrane protein insertase YidC -
EL036_RS11160 2174595..2175236 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T286985 WP_000581792.1 NZ_LR134193:c2170529-2170320 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11184.82 Da        Isoelectric Point: 6.2243

>AT286985 WP_000138928.1 NZ_LR134193:c2170834-2170541 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References