Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2150564..2151093 Replicon chromosome
Accession NZ_LR134193
Organism Staphylococcus aureus strain NCTC13616

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL036_RS11040 Protein ID WP_000621175.1
Coordinates 2150564..2150926 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL036_RS11045 Protein ID WP_000948330.1
Coordinates 2150923..2151093 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL036_RS11015 2147542..2148312 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
EL036_RS11020 2148287..2148766 - 480 WP_001190825.1 anti-sigma B factor RsbW -
EL036_RS11025 2148768..2149094 - 327 WP_001052491.1 anti-sigma factor antagonist -
EL036_RS11030 2149214..2150215 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
EL036_RS11040 2150564..2150926 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL036_RS11045 2150923..2151093 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EL036_RS11050 2151178..2152326 - 1149 WP_001281141.1 alanine racemase -
EL036_RS11055 2152392..2152751 - 360 WP_000581193.1 holo-ACP synthase -
EL036_RS11060 2152755..2153246 - 492 WP_001205918.1 PH domain-containing protein -
EL036_RS11065 2153233..2154816 - 1584 WP_001294624.1 PH domain-containing protein -
EL036_RS11070 2154809..2155288 - 480 WP_001287080.1 hypothetical protein -
EL036_RS11075 2155497..2156057 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286984 WP_000621175.1 NZ_LR134193:c2150926-2150564 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT286984 WP_000948330.1 NZ_LR134193:c2151093-2150923 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References