Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 349669..350471 Replicon chromosome
Accession NC_019973
Organism Mesorhizobium australicum WSM2073

Toxin (Protein)


Gene name TacT3 Uniprot ID L0KFK0
Locus tag MESAU_RS01600 Protein ID WP_015314301.1
Coordinates 349944..350471 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID L0KC16
Locus tag MESAU_RS01595 Protein ID WP_015314300.1
Coordinates 349669..349947 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MESAU_RS01570 345232..346116 - 885 WP_041163585.1 DMT family transporter -
MESAU_RS01575 346311..346718 - 408 WP_015314296.1 DUF2000 family protein -
MESAU_RS01580 346772..347641 + 870 WP_015314297.1 AraC family transcriptional regulator -
MESAU_RS01585 347654..348124 - 471 WP_015314298.1 MarR family transcriptional regulator -
MESAU_RS01590 348547..349590 + 1044 WP_015314299.1 GTP-binding protein -
MESAU_RS01595 349669..349947 + 279 WP_015314300.1 DUF1778 domain-containing protein Antitoxin
MESAU_RS01600 349944..350471 + 528 WP_015314301.1 hypothetical protein Toxin
MESAU_RS01605 350573..351547 + 975 WP_015314302.1 WD40 repeat domain-containing protein -
MESAU_RS01610 351561..352013 - 453 WP_015314303.1 hypothetical protein -
MESAU_RS01615 352171..353550 + 1380 WP_015314304.1 aspartate aminotransferase family protein -
MESAU_RS01620 353583..354968 + 1386 WP_015314305.1 glutamine synthetase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(12-87)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18646.32 Da        Isoelectric Point: 8.2948

>T28698 WP_015314301.1 NC_019973:349944-350471 [Mesorhizobium australicum WSM2073]
VTLPSWHEEPIAKRHDRASFDCGDLQMNEFLQRFARQSHDQNAAKTFCAIGDTASERVLGFYTIAPSAVAHEAVPAALTR
GLARHEVSGFKLGRLATDRTVAGQGLGGQLLAAAALRCLRLAGEGGGILLIIDAKSERAAKWYASYGAERLTGSDLTLVM
PLAAFAADLRAKGLL

Download         Length: 528 bp

>T28698 NC_019973:349944-350471 [Mesorhizobium australicum WSM2073]
GTGACTCTTCCGTCCTGGCACGAGGAGCCAATAGCAAAACGCCACGATCGAGCGTCCTTCGATTGTGGCGACCTGCAGAT
GAACGAATTTCTGCAGCGGTTCGCGCGACAGAGTCATGATCAGAATGCGGCCAAGACCTTCTGCGCGATCGGCGATACAG
CTTCGGAACGTGTACTCGGTTTTTATACGATCGCGCCGTCCGCCGTCGCTCATGAAGCCGTTCCCGCAGCCCTGACGAGA
GGCTTGGCACGACACGAAGTTTCCGGCTTCAAGCTTGGCCGTCTTGCCACCGATCGCACCGTCGCCGGGCAAGGCCTCGG
AGGTCAGTTGCTTGCCGCGGCGGCATTGCGCTGCCTGCGGCTTGCGGGAGAAGGGGGCGGCATTCTGCTCATCATCGACG
CCAAGAGCGAGCGGGCGGCAAAGTGGTATGCAAGCTACGGCGCCGAGCGTCTCACAGGATCGGATTTGACTCTGGTAATG
CCGTTGGCAGCATTCGCTGCGGATCTACGAGCCAAGGGGCTGCTTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10152.86 Da        Isoelectric Point: 9.7658

>AT28698 WP_015314300.1 NC_019973:349669-349947 [Mesorhizobium australicum WSM2073]
MPRPADNKTERYQIRIPPSEKAMIARAAALSHKDMADFILDKIVPAAQAVIDAAEVTKVSDRDFKRILDLLEHPPKPNAR
LKAAIAALPDTL

Download         Length: 279 bp

>AT28698 NC_019973:349669-349947 [Mesorhizobium australicum WSM2073]
ATGCCTAGACCTGCGGACAACAAGACCGAGCGCTACCAAATCCGCATTCCCCCTTCGGAGAAGGCGATGATCGCGCGCGC
CGCTGCGCTCTCGCACAAAGACATGGCAGACTTCATCCTCGATAAGATCGTGCCTGCGGCGCAGGCGGTGATTGATGCGG
CTGAAGTGACGAAGGTGTCCGACCGCGACTTTAAGCGCATCCTGGACCTGCTGGAACACCCGCCAAAACCCAACGCCAGG
CTCAAGGCGGCGATTGCGGCCTTGCCGGACACTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A503DS09

Antitoxin

Source ID Structure
AlphaFold DB A0A503DZ92

References