Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3843603..3844189 Replicon chromosome
Accession NZ_LR134189
Organism Providencia rustigianii strain NCTC6933

Toxin (Protein)


Gene name PumA Uniprot ID D1P7T6
Locus tag EL059_RS18020 Protein ID WP_006816297.1
Coordinates 3843887..3844189 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EL059_RS18015 Protein ID WP_006816296.1
Coordinates 3843603..3843890 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL059_RS17990 3839783..3839995 + 213 WP_006816290.1 RNA chaperone/antiterminator CspA -
EL059_RS17995 3840125..3841069 - 945 WP_006816291.1 phosphatidate cytidylyltransferase -
EL059_RS18000 3841066..3841707 - 642 WP_039855930.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
EL059_RS18005 3841919..3842674 - 756 WP_006816294.1 M48 family metallopeptidase -
EL059_RS18010 3842897..3843478 - 582 WP_006816295.1 HutD family protein -
EL059_RS18015 3843603..3843890 - 288 WP_006816296.1 putative addiction module antidote protein Antitoxin
EL059_RS18020 3843887..3844189 - 303 WP_006816297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL059_RS18025 3844413..3844979 - 567 WP_006816217.1 Spy/CpxP family protein refolding chaperone -
EL059_RS18030 3845131..3845829 + 699 WP_006816216.1 envelope stress response regulator transcription factor CpxR -
EL059_RS18035 3845826..3847196 + 1371 WP_006816215.1 envelope stress sensor histidine kinase CpxA -
EL059_RS18040 3848183..3849013 + 831 WP_198434883.1 polysaccharide pyruvyl transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11597.41 Da        Isoelectric Point: 10.0958

>T286973 WP_006816297.1 NZ_LR134189:c3844189-3843887 [Providencia rustigianii]
MLTVFTTDIFDKWMHELKDIRAKTKIQVRIRRLKNGNFGDVESIGEGFSELKIHEGKGYRVYLKKVENTIVLLINGGSKS
TQQKDIDRAKQIFREIEGDL

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10595.29 Da        Isoelectric Point: 5.7011

>AT286973 WP_006816296.1 NZ_LR134189:c3843890-3843603 [Providencia rustigianii]
MSIKIKEYDIAEHLASEEEIQLYLNEILEEGDPALILSALGDIARARNMTQLAKDVGMSREGLYKALSGQGNPTFTTIMK
IVHSLGFKLQFKRAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1P7T6

Antitoxin

Source ID Structure

References