Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2485878..2486533 Replicon chromosome
Accession NZ_LR134189
Organism Providencia rustigianii strain NCTC6933

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL059_RS11525 Protein ID WP_071599550.1
Coordinates 2485878..2486063 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D1P354
Locus tag EL059_RS11530 Protein ID WP_006814675.1
Coordinates 2486120..2486533 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL059_RS11505 2481791..2482879 - 1089 WP_006814671.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
EL059_RS11510 2482882..2483742 - 861 WP_006814672.1 sulfate/thiosulfate ABC transporter permease CysW -
EL059_RS11515 2483742..2484572 - 831 WP_006814673.1 sulfate/thiosulfate ABC transporter permease CysT -
EL059_RS11520 2484572..2485594 - 1023 WP_006814674.1 sulfate ABC transporter substrate-binding protein -
EL059_RS11525 2485878..2486063 + 186 WP_071599550.1 type II toxin-antitoxin system HicA family toxin Toxin
EL059_RS11530 2486120..2486533 + 414 WP_006814675.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL059_RS11535 2486591..2487487 - 897 WP_006814676.1 Dyp-type peroxidase -
EL059_RS11540 2487702..2488286 - 585 WP_039855044.1 RpoE-regulated lipoprotein -
EL059_RS11545 2488368..2488799 - 432 WP_006814678.1 GNAT family acetyltransferase -
EL059_RS11550 2488935..2489852 + 918 WP_006814679.1 oxygen-dependent coproporphyrinogen oxidase -
EL059_RS11555 2490010..2491143 + 1134 WP_006814680.1 M4 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7064.36 Da        Isoelectric Point: 11.2336

>T286971 WP_071599550.1 NZ_LR134189:2485878-2486063 [Providencia rustigianii]
MKSSELIKLLEKNGWRLERIKGSHHQFSHPNFSIVITVPHPRKDLKIGTLNQILTVAKLKH

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15388.27 Da        Isoelectric Point: 4.9767

>AT286971 WP_006814675.1 NZ_LR134189:2486120-2486533 [Providencia rustigianii]
MLYPAFIEIDSDGSASGWFPDIEGCTFAGDNIEDAYADAKSAIDVHFELLSEKGFKIPSPKSQHAHLQDTPDIYQKGIWL
LVDIDMDKYDGRAERVNITLPHRLLHRIDTLVKEHPEYGSRSGFIAAAARKELQKNS

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379G4X3

References