Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 875787..876430 Replicon chromosome
Accession NZ_LR134189
Organism Providencia rustigianii strain NCTC6933

Toxin (Protein)


Gene name Hha Uniprot ID D1P676
Locus tag EL059_RS03945 Protein ID WP_006815740.1
Coordinates 875787..875990 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D1P675
Locus tag EL059_RS03950 Protein ID WP_006815739.1
Coordinates 876062..876430 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL059_RS03920 872049..872916 - 868 Protein_762 acyl-CoA thioesterase II -
EL059_RS03925 873158..873400 + 243 Protein_763 endopeptidase -
EL059_RS03930 873465..874978 + 1514 WP_096746888.1 IS3 family transposase -
EL059_RS03935 875015..875233 + 219 WP_126436404.1 YbaY family lipoprotein -
EL059_RS03945 875787..875990 - 204 WP_006815740.1 hemolysin expression modulator Hha Toxin
EL059_RS03950 876062..876430 - 369 WP_006815739.1 Hha toxicity modulator TomB Antitoxin
EL059_RS03955 876959..878335 - 1377 WP_006815738.1 murein transglycosylase D -
EL059_RS03960 878419..879171 - 753 WP_006815737.1 hydroxyacylglutathione hydrolase -
EL059_RS03965 879206..879931 + 726 WP_006815736.1 class I SAM-dependent methyltransferase -
EL059_RS03970 879940..880411 - 472 Protein_771 ribonuclease HI -
EL059_RS03975 880466..881227 + 762 WP_006815734.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T286966 WP_006815740.1 NZ_LR134189:c875990-875787 [Providencia rustigianii]
MTKSDYLMRLRKCTTLETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14120.98 Da        Isoelectric Point: 4.3849

>AT286966 WP_006815739.1 NZ_LR134189:c876430-876062 [Providencia rustigianii]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTTTHWINDLSSPLSVSLNELVEHITSFVWRFKIKYPKENLVISLVEEYL
DETYDLFGSPVITFSEITDWESMNQNLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379G0S0

Antitoxin

Source ID Structure
AlphaFold DB A0A379G117

References