Detailed information of TA system TA286964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 586844..587880
• Replicon: chromosome
• Accession: NZ_LR134189
• Organism: Providencia rustigianii strain NCTC6933

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: EL059_RS02660
• Protein ID: WP_112836092.1
• Coordinates: 586844..587419 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: EL059_RS02665
• Protein ID: WP_112836094.1
• Coordinates: 587419..587880 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL059_RS02640	582596..583627	+	1032	WP_006816007.1	carbon-nitrogen hydrolase family protein	-
EL059_RS02645	583681..584380	+	700	Protein_511	Asp/Glu racemase	-
EL059_RS02650	584466..584918	+	453	WP_039855745.1	MarR family transcriptional regulator	-
EL059_RS02655	585195..586841	+	1647	WP_115163934.1	Na+/H+ antiporter	-
EL059_RS02660	586844..587419	-	576	WP_112836092.1	PIN domain-containing protein	Toxin
EL059_RS02665	587419..587880	-	462	WP_112836094.1	helix-turn-helix domain-containing protein	Antitoxin
EL059_RS02670	588071..588691	-	621	WP_006816000.1	flavin reductase family protein	-
EL059_RS02675	589445..589789	+	345	WP_006815999.1	helix-turn-helix transcriptional regulator	-
EL059_RS02680	589910..590461	+	552	WP_006815998.1	type 1 fimbrial protein	-
EL059_RS02685	590525..591106	+	582	WP_039855740.1	type 1 fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21909.71 Da
• Isoelectric Point: 7.9326

>T286964 WP_112836092.1 NZ_LR134189:c587419-586844 [Providencia rustigianii]
MIHSPFPVVLDACVLYPSLLRDLLMHLAIAGLYQAKWTDVIHNEWQRNLLINRPDLSTSQLNRTSALMNIALPDAKVEQY
EPLIDGLELPDLDDRHVVAAAIKSNAKIIVTLNLKDFPKKYLKRLDMEALHPDEFISDLFDLNHALALSAVRKQRINLKK
PKINTREYFDALLRQGLPMTVKALEKYQCMI

Nucleotide

• Length: 576 bp

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 16924.62 Da
• Isoelectric Point: 6.9911

>AT286964 WP_112836094.1 NZ_LR134189:c587880-587419 [Providencia rustigianii]
MTYSILKGMSLPAPKEIEAAVKGQRELATYLSTKLETQQISIKDADNKVHQIELPTSALTLLMAILGELAAGNAVQIVPV
HAELTTQEAANILNVSRPHLVKLLEAGRLPFHKTGRHRRILFADLMQFKAQREEESLQAMQALADQSQELGLY

Nucleotide

• Length: 462 bp