Detailed information of TA system TA286962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2073155..2074273
• Replicon: chromosome
• Accession: NZ_LR134178
• Organism: Legionella sainthelensi strain NCTC12450

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EL064_RS08920
• Protein ID: WP_128129918.1
• Coordinates: 2073155..2073907 (-)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EL064_RS08925
• Protein ID: WP_115707238.1
• Coordinates: 2073908..2074273 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL064_RS08895	2068523..2069734	+	1212	WP_128129917.1	sterol desaturase family protein	-
EL064_RS08900	2069822..2070025	-	204	WP_101900612.1	DUF1328 domain-containing protein	-
EL064_RS08905	2070323..2070772	+	450	WP_115701352.1	CBS domain-containing protein	-
EL064_RS08910	2070824..2071378	+	555	WP_101900614.1	HPF/RaiA family ribosome-associated protein	-
EL064_RS08915	2071549..2072461	+	913	Protein_1734	SAM-dependent methyltransferase	-
EL064_RS08920	2073155..2073907	-	753	WP_128129918.1	RES family NAD+ phosphorylase	Toxin
EL064_RS08925	2073908..2074273	-	366	WP_115707238.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
EL064_RS08930	2074482..2075651	-	1170	WP_128129919.1	hypothetical protein	-
EL064_RS08935	2076002..2077759	+	1758	WP_128129920.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	pilB / pilC / pilD	1802718..2182538	379820

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (65-208)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-119)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 28740.51 Da
• Isoelectric Point: 5.7977

>T286962 WP_128129918.1 NZ_LR134178:c2073907-2073155 [Legionella sainthelensi]
MVDIWIESEGKNHIKPLIVKIYRLVESQEQIATLGLVNNVYEQGILEDLIESTKSPLSENTSSLHYLLTTPFRYPPLKYG
SRFGTTFEQGIFYGSLNIRTALSETAYYRFVYMLGPETPYEHPISNQYSSFSVKVRSEKGIFLDQAPFLKYEETLTSPSS
YNDTQQLGSKMRENDIEIFQYTSARDKNKGKNVALFTPKAFQSKVPAQITTWLCQTSIEEVGFIEKEGQQRISFLQKDFW
VRDTFPSPAT

Nucleotide

• Length: 753 bp

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13557.79 Da
• Isoelectric Point: 10.2601

>AT286962 WP_115707238.1 NZ_LR134178:c2074273-2073908 [Legionella sainthelensi]
MKIESKPSENQVLATALDNLRGILHISINDISEIIGVHRNTLRNALNSKNLETKSKEGECSLLLIRIYRSLFALNGGNVD
AMIHWLRTNNRHIQGVPLETMKTILGLSKVVNYLDAIRGKI

Nucleotide

• Length: 366 bp