Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3027176..3028725 Replicon chromosome
Accession NZ_LR134173
Organism Legionella cherrii strain NCTC11976

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL022_RS12875 Protein ID WP_028380189.1
Coordinates 3027418..3028725 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0W0S903
Locus tag EL022_RS12870 Protein ID WP_028380190.1
Coordinates 3027176..3027424 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL022_RS12850 3022793..3023845 - 1053 WP_028380192.1 alkane 1-monooxygenase -
EL022_RS12855 3024046..3025020 + 975 WP_051544427.1 hypothetical protein -
EL022_RS12860 3025168..3026250 - 1083 WP_028380191.1 DUF3541 domain-containing protein -
EL022_RS12865 3026392..3026997 + 606 WP_051544404.1 hypothetical protein -
EL022_RS12870 3027176..3027424 + 249 WP_028380190.1 helix-turn-helix domain-containing protein Antitoxin
EL022_RS12875 3027418..3028725 + 1308 WP_028380189.1 type II toxin-antitoxin system HipA family toxin Toxin
EL022_RS12880 3028956..3029816 + 861 WP_028380188.1 polysaccharide deacetylase family protein -
EL022_RS12885 3029966..3031180 - 1215 WP_028380187.1 murein transglycosylase A -
EL022_RS12890 3031499..3033619 - 2121 WP_028380186.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(152-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49773.32 Da        Isoelectric Point: 8.0081

>T286959 WP_028380189.1 NZ_LR134173:3027418-3028725 [Legionella cherrii]
MVKKNQTLYVLMNGILVGMLEKTAQGGLRFTYHHDWLTQAGSRPISLSLPLINPTYSGDVVYNFFDNLLPDNQQIRARIQ
ARFQIATSQPFDLLAGIGRDCVGAIQLVTAPLVEFEKKIKFKPVSEQKIASILRNYRINPLGMSQEDEDFRISIAGAQEK
TAFLYHENQWCEPLQETPTTHIFKLPIGVIAHQQMDLSDSCENEWLCSLLAKSYGLPVADCNILHFEDVKVLSVKRFDRR
LSRDKSWIMRLPQEDMCQALGVSYNIKYQSDGGPGIKEIMNLLLGSANSIADRDMFYRAQVFFWLLAAIDGHAKNFSLFI
EAEGKYRLSPLYDIISAYPLIKKNQLQSQKIKMAMALKGKNNHYHWHTLQRRHFLDTSKDANYSSDRAEMILNDMLEKTD
SVIQEVSKKLPAEFPNHISEPIFEGLHKAKQKLEQ

Download         Length: 1308 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9336.78 Da        Isoelectric Point: 9.9526

>AT286959 WP_028380190.1 NZ_LR134173:3027176-3027424 [Legionella cherrii]
MLIHSPQELALLIKNQRKKLKLSQAEVADLVGLKQKTISAIENNPENMRLSTLFRILSALSLDFKASTKSEQTTTNPWND
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0S903

References