Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1617916..1618450 Replicon chromosome
Accession NZ_LR134171
Organism Haemophilus influenzae strain NCTC12699

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ELZ63_RS07990 Protein ID WP_065245132.1
Coordinates 1618160..1618450 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag ELZ63_RS07985 Protein ID WP_005651514.1
Coordinates 1617916..1618170 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ63_RS07950 1613235..1613495 + 261 WP_005663579.1 hypothetical protein -
ELZ63_RS07955 1613525..1613889 + 365 Protein_1513 DUF559 domain-containing protein -
ELZ63_RS07960 1614513..1616579 + 2067 WP_065245135.1 glycine--tRNA ligase subunit beta -
ELZ63_RS07970 1617078..1617386 + 309 WP_065245134.1 P2 family phage major capsid protein -
ELZ63_RS07975 1617386..1617610 + 225 WP_065245133.1 hypothetical protein -
ELZ63_RS07980 1617619..1617825 + 207 WP_038440120.1 hypothetical protein -
ELZ63_RS07985 1617916..1618170 + 255 WP_005651514.1 stability protein StbD Antitoxin
ELZ63_RS07990 1618160..1618450 + 291 WP_065245132.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELZ63_RS09350 1618886..1619023 + 138 WP_164550136.1 hypothetical protein -
ELZ63_RS08000 1619493..1620527 - 1035 WP_065245131.1 DNA polymerase III subunit delta -
ELZ63_RS08005 1620527..1621030 - 504 WP_065245130.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11481.47 Da        Isoelectric Point: 10.8143

>T286958 WP_065245132.1 NZ_LR134171:1618160-1618450 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGKTLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT286958 WP_005651514.1 NZ_LR134171:1617916-1618170 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References