Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 968903..969438 Replicon chromosome
Accession NZ_LR134171
Organism Haemophilus influenzae strain NCTC12699

Toxin (Protein)


Gene name relE Uniprot ID E7A433
Locus tag ELZ63_RS04775 Protein ID WP_013525737.1
Coordinates 969175..969438 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A432
Locus tag ELZ63_RS04770 Protein ID WP_013525736.1
Coordinates 968903..969178 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ63_RS04750 964306..966345 - 2040 WP_065245373.1 excinuclease ABC subunit B -
ELZ63_RS04760 966961..967929 - 969 WP_038441067.1 zinc transporter permease subunit ZevB -
ELZ63_RS04765 967932..968552 - 621 WP_065245372.1 zinc transporter binding subunit ZevA -
ELZ63_RS04770 968903..969178 + 276 WP_013525736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ELZ63_RS04775 969175..969438 + 264 WP_013525737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ELZ63_RS04780 969533..971203 + 1671 WP_005663485.1 energy-dependent translational throttle protein EttA -
ELZ63_RS04785 971265..971606 + 342 WP_005652996.1 SirB2 family protein -
ELZ63_RS04790 971611..973581 + 1971 WP_061723981.1 tRNA(Met) cytidine acetyltransferase TmcA -
ELZ63_RS09330 973578..973751 + 174 WP_005657572.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T286956 WP_013525737.1 NZ_LR134171:969175-969438 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.81 Da        Isoelectric Point: 6.0646

>AT286956 WP_013525736.1 NZ_LR134171:968903-969178 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QSH1

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R2R7

References