286955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 12999..13603 Replicon chromosome
Accession NZ_LR134171
Organism Haemophilus influenzae strain NCTC12699

Toxin (Protein)


Gene name relE Uniprot ID Q4QMK7
Locus tag ELZ63_RS00055 Protein ID WP_011272186.1
Coordinates 12999..13307 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ELZ63_RS00060 Protein ID WP_065245463.1
Coordinates 13307..13603 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ63_RS00040 8759..8998 - 240 WP_005651317.1 hypothetical protein -
ELZ63_RS00050 9751..12942 + 3192 WP_126466918.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
ELZ63_RS00055 12999..13307 - 309 WP_011272186.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ELZ63_RS00060 13307..13603 - 297 WP_065245463.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ELZ63_RS00065 13723..14577 - 855 WP_048954823.1 DUF3298 domain-containing protein -
ELZ63_RS00070 14596..16455 - 1860 WP_065245464.1 selenocysteine-specific translation elongation factor -
ELZ63_RS00075 16452..17837 - 1386 WP_065245465.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11929.69 Da        Isoelectric Point: 7.8904

>T286955 WP_011272186.1 NZ_LR134171:c13307-12999 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IHDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT286955 WP_065245463.1 NZ_LR134171:c13603-13307 [Haemophilus influenzae]
MAITNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QMK7

Antitoxin

Source ID Structure

References