Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1846268..1846999 Replicon chromosome
Accession NZ_LR134169
Organism Actinobacillus lignieresii strain NCTC10568

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag ELZ64_RS08835 Protein ID WP_115587609.1
Coordinates 1846268..1846735 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag ELZ64_RS08840 Protein ID WP_005619269.1
Coordinates 1846739..1846999 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ64_RS08810 1841626..1841997 - 372 WP_005598830.1 CrcB family protein -
ELZ64_RS08815 1842000..1843064 - 1065 WP_126375245.1 MFS transporter -
ELZ64_RS08820 1843159..1844267 + 1109 Protein_1718 anhydro-N-acetylmuramic acid kinase -
ELZ64_RS08825 1844321..1845235 + 915 WP_126375247.1 N-acetylmuramic acid 6-phosphate etherase -
ELZ64_RS08830 1845302..1846183 - 882 WP_115587608.1 50S ribosomal protein L11 methyltransferase -
ELZ64_RS08835 1846268..1846735 - 468 WP_115587609.1 GNAT family N-acetyltransferase Toxin
ELZ64_RS08840 1846739..1846999 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
ELZ64_RS08845 1847119..1848579 - 1461 WP_126375249.1 metalloprotease TldD -
ELZ64_RS08850 1848709..1849968 + 1260 WP_126375251.1 tRNA lysidine(34) synthetase TilS -
ELZ64_RS08855 1849995..1850285 - 291 WP_005598848.1 DUF5389 family protein -
ELZ64_RS08860 1850287..1851180 - 894 WP_115590816.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17197.17 Da        Isoelectric Point: 8.9527

>T286953 WP_115587609.1 NZ_LR134169:c1846735-1846268 [Actinobacillus lignieresii]
MHAPELLSEQHIVRHFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNQQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT286953 WP_005619269.1 NZ_LR134169:c1846999-1846739 [Actinobacillus lignieresii]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References