Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1567075..1567583 Replicon chromosome
Accession NZ_LR134169
Organism Actinobacillus lignieresii strain NCTC10568

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ELZ64_RS07420 Protein ID WP_009875288.1
Coordinates 1567323..1567583 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A3N1S6
Locus tag ELZ64_RS07415 Protein ID WP_005605062.1
Coordinates 1567075..1567326 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ64_RS07375 1562609..1563157 - 549 WP_126375080.1 type IV pilus biogenesis/stability protein PilW -
ELZ64_RS07380 1563211..1564392 - 1182 WP_115587407.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
ELZ64_RS07405 1565298..1566737 + 1440 WP_126375081.1 glutamate--tRNA ligase -
ELZ64_RS07415 1567075..1567326 + 252 WP_005605062.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ELZ64_RS07420 1567323..1567583 + 261 WP_009875288.1 Txe/YoeB family addiction module toxin Toxin
ELZ64_RS07425 1567740..1567907 - 168 WP_009875287.1 Trm112 family protein -
ELZ64_RS07430 1567909..1568889 - 981 WP_126375082.1 tetraacyldisaccharide 4'-kinase -
ELZ64_RS07435 1568983..1570242 - 1260 WP_126375083.1 ATP-dependent protease ATP-binding subunit ClpX -
ELZ64_RS07440 1570242..1570832 - 591 WP_005601821.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
ELZ64_RS07445 1570956..1571348 + 393 WP_005618838.1 SufE family protein -
ELZ64_RS07460 1571708..1572484 - 777 WP_115587412.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10452.00 Da        Isoelectric Point: 8.0109

>T286952 WP_009875288.1 NZ_LR134169:1567323-1567583 [Actinobacillus lignieresii]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYTVEDETILIVAC
RYHYDQ

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9320.62 Da        Isoelectric Point: 4.5659

>AT286952 WP_005605062.1 NZ_LR134169:1567075-1567326 [Actinobacillus lignieresii]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N1S6

References