Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 358225..358696 Replicon chromosome
Accession NZ_LR134168
Organism Haemophilus influenzae strain NCTC11394

Toxin (Protein)


Gene name toxT Uniprot ID A0A806DTA9
Locus tag ELZ62_RS01795 Protein ID WP_005654546.1
Coordinates 358225..358407 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag ELZ62_RS01800 Protein ID WP_112063261.1
Coordinates 358400..358696 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ62_RS01790 355043..357955 + 2913 WP_126507560.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
ELZ62_RS01795 358225..358407 + 183 WP_005654546.1 shikimate 5-dehydrogenase Toxin
ELZ62_RS01800 358400..358696 + 297 WP_112063261.1 helix-turn-helix transcriptional regulator Antitoxin
ELZ62_RS01805 358880..360796 + 1917 WP_112063262.1 ABC transporter ATP-binding protein -
ELZ62_RS01810 360806..361342 + 537 WP_112063263.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
ELZ62_RS01815 361358..361909 + 552 WP_112063264.1 Sua5/YciO/YrdC/YwlC family protein -
ELZ62_RS01820 361913..362719 + 807 WP_112063265.1 shikimate dehydrogenase -
ELZ62_RS01825 362933..363496 + 564 WP_048941097.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7318.33 Da        Isoelectric Point: 6.3057

>T286947 WP_005654546.1 NZ_LR134168:358225-358407 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Download         Length: 183 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11120.01 Da        Isoelectric Point: 10.7759

>AT286947 WP_112063261.1 NZ_LR134168:358400-358696 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRKSNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVRNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DTA9

Antitoxin

Source ID Structure

References