Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 299978..300582 Replicon chromosome
Accession NZ_LR134168
Organism Haemophilus influenzae strain NCTC11394

Toxin (Protein)


Gene name relE Uniprot ID A0A822VCP0
Locus tag ELZ62_RS01515 Protein ID WP_015701819.1
Coordinates 299978..300286 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag ELZ62_RS01520 Protein ID WP_005692346.1
Coordinates 300286..300582 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ62_RS01505 295164..296462 - 1299 WP_015701821.1 trigger factor -
ELZ62_RS01510 296817..299921 + 3105 WP_126507554.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
ELZ62_RS01515 299978..300286 - 309 WP_015701819.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ELZ62_RS01520 300286..300582 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ELZ62_RS01525 300702..301556 - 855 WP_015701818.1 DUF3298 domain-containing protein -
ELZ62_RS01530 301575..303434 - 1860 WP_015701817.1 selenocysteine-specific translation elongation factor -
ELZ62_RS01535 303431..304816 - 1386 WP_015701816.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11919.74 Da        Isoelectric Point: 8.9408

>T286945 WP_015701819.1 NZ_LR134168:c300286-299978 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDKFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT286945 WP_005692346.1 NZ_LR134168:c300582-300286 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822VCP0

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References