Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 76798..77332 Replicon chromosome
Accession NZ_LR134168
Organism Haemophilus influenzae strain NCTC11394

Toxin (Protein)


Gene name relE Uniprot ID Q849T7
Locus tag ELZ62_RS00395 Protein ID WP_015701940.1
Coordinates 77042..77332 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X4XNI1
Locus tag ELZ62_RS00390 Protein ID WP_015701941.1
Coordinates 76798..77052 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ62_RS00355 72383..72643 + 261 WP_005651528.1 hypothetical protein -
ELZ62_RS00360 72673..73038 + 366 WP_015701945.1 endonuclease domain-containing protein -
ELZ62_RS00365 73375..75441 + 2067 WP_015701944.1 glycine--tRNA ligase subunit beta -
ELZ62_RS00375 75960..76268 + 309 Protein_71 P2 family phage major capsid protein -
ELZ62_RS00380 76268..76492 + 225 WP_015701942.1 hypothetical protein -
ELZ62_RS00385 76501..76707 + 207 WP_041175054.1 hypothetical protein -
ELZ62_RS00390 76798..77052 + 255 WP_015701941.1 stability protein StbD Antitoxin
ELZ62_RS00395 77042..77332 + 291 WP_015701940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELZ62_RS09360 77789..77926 + 138 WP_005663612.1 hypothetical protein -
ELZ62_RS00405 78394..79428 - 1035 WP_015701939.1 DNA polymerase III subunit delta -
ELZ62_RS00410 79428..79931 - 504 WP_015701938.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11496.44 Da        Isoelectric Point: 10.6484

>T286944 WP_015701940.1 NZ_LR134168:77042-77332 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSIGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9449.81 Da        Isoelectric Point: 4.0737

>AT286944 WP_015701941.1 NZ_LR134168:76798-77052 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELSRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q849T7

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XNI1

References