Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 48193..48824 Replicon chromosome
Accession NZ_LR134168
Organism Haemophilus influenzae strain NCTC11394

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag ELZ62_RS00245 Protein ID WP_005651560.1
Coordinates 48426..48824 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2X4XKC3
Locus tag ELZ62_RS00240 Protein ID WP_015701961.1
Coordinates 48193..48426 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ62_RS00215 43673..44875 - 1203 WP_015701964.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
ELZ62_RS00220 45038..45703 + 666 WP_013527272.1 DNA repair protein RadC -
ELZ62_RS00225 45917..46153 + 237 WP_005542826.1 50S ribosomal protein L28 -
ELZ62_RS00230 46165..46335 + 171 WP_005613503.1 50S ribosomal protein L33 -
ELZ62_RS00235 46682..48046 + 1365 WP_015701962.1 diaminobutyrate--2-oxoglutarate transaminase -
ELZ62_RS00240 48193..48426 + 234 WP_015701961.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
ELZ62_RS00245 48426..48824 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
ELZ62_RS00250 48844..50379 + 1536 WP_015701960.1 L-2,4-diaminobutyrate decarboxylase -
ELZ62_RS00255 50610..51425 + 816 WP_015701959.1 DNA-formamidopyrimidine glycosylase -
ELZ62_RS00260 51499..52521 - 1023 WP_015701958.1 outer membrane-stress sensor serine endopeptidase DegS -
ELZ62_RS00265 52522..53640 - 1119 WP_015701957.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T286943 WP_005651560.1 NZ_LR134168:48426-48824 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8911.01 Da        Isoelectric Point: 4.4013

>AT286943 WP_015701961.1 NZ_LR134168:48193-48426 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQTVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XKC3

References