Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1869712..1870298 Replicon chromosome
Accession NZ_LR134167
Organism Avibacterium volantium strain NCTC3438

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ELZ61_RS08840 Protein ID WP_126373019.1
Coordinates 1869712..1869960 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ELZ61_RS08845 Protein ID WP_103853212.1
Coordinates 1869957..1870298 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ61_RS08825 1865884..1867083 + 1200 WP_126373013.1 tyrosine--tRNA ligase -
ELZ61_RS08830 1867260..1868189 + 930 WP_126373015.1 aminoimidazole riboside kinase -
ELZ61_RS08835 1868201..1869652 + 1452 WP_126373017.1 glycoside hydrolase family 32 protein -
ELZ61_RS08840 1869712..1869960 + 249 WP_126373019.1 type II toxin-antitoxin system HicA family toxin Toxin
ELZ61_RS08845 1869957..1870298 + 342 WP_103853212.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ELZ61_RS08850 1870393..1870869 + 477 WP_126373021.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
ELZ61_RS08855 1870920..1872266 + 1347 WP_126373023.1 N-acetylmuramoyl-L-alanine amidase -
ELZ61_RS08860 1872289..1874250 + 1962 WP_126373025.1 DNA mismatch repair endonuclease MutL -
ELZ61_RS08865 1874250..1875176 + 927 WP_126373027.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9233.88 Da        Isoelectric Point: 10.2543

>T286940 WP_126373019.1 NZ_LR134167:1869712-1869960 [Avibacterium volantium]
MGKSEKLLEKLANAKNTFIWTDLLTLLARLGYEKREMAGSRVRFYNAELDHLILLHKPHPENYIKGGALKSVKDGLKGVG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12696.47 Da        Isoelectric Point: 4.5942

>AT286940 WP_103853212.1 NZ_LR134167:1869957-1870298 [Avibacterium volantium]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVVTYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References