Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1460678..1461597 Replicon chromosome
Accession NZ_LR134165
Organism Bacillus paralicheniformis strain NCTC8721

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7TYV7
Locus tag EL050_RS07480 Protein ID WP_023856735.1
Coordinates 1460851..1461597 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7TM13
Locus tag EL050_RS07475 Protein ID WP_023856734.1
Coordinates 1460678..1460851 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL050_RS07455 1456103..1457200 + 1098 WP_025811596.1 mannonate dehydratase -
EL050_RS07460 1457176..1458024 + 849 WP_025811594.1 SDR family oxidoreductase -
EL050_RS07465 1458050..1459063 + 1014 WP_025811592.1 zinc-binding alcohol dehydrogenase family protein -
EL050_RS07470 1459115..1460386 + 1272 WP_025811590.1 MFS transporter -
EL050_RS07475 1460678..1460851 - 174 WP_023856734.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
EL050_RS07480 1460851..1461597 - 747 WP_023856735.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EL050_RS07485 1461707..1462705 - 999 WP_023856736.1 inorganic phosphate transporter -
EL050_RS07490 1462718..1463335 - 618 WP_023856737.1 DUF47 domain-containing protein -
EL050_RS07495 1463668..1465425 + 1758 WP_025811589.1 gamma-glutamyltransferase -
EL050_RS07500 1465560..1466204 + 645 WP_023856740.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29421.87 Da        Isoelectric Point: 4.6015

>T286936 WP_023856735.1 NZ_LR134165:c1461597-1460851 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Download         Length: 747 bp

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.8356

>AT286936 WP_023856734.1 NZ_LR134165:c1460851-1460678 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7TYV7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7TM13

References