Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 581281..581917 Replicon chromosome
Accession NZ_LR134165
Organism Bacillus paralicheniformis strain NCTC8721

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag EL050_RS02910 Protein ID WP_003179128.1
Coordinates 581567..581917 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag EL050_RS02905 Protein ID WP_006638778.1
Coordinates 581281..581562 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL050_RS02885 576392..577876 + 1485 WP_023857868.1 PH domain-containing protein -
EL050_RS02890 577873..578472 - 600 WP_023857867.1 rhomboid family intramembrane serine protease -
EL050_RS02895 578816..579775 + 960 WP_164468292.1 outer membrane lipoprotein carrier protein LolA -
EL050_RS02900 580000..581169 + 1170 WP_023857864.1 alanine racemase -
EL050_RS02905 581281..581562 + 282 WP_006638778.1 hypothetical protein Antitoxin
EL050_RS02910 581567..581917 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
EL050_RS02915 582035..582862 + 828 WP_025810067.1 RsbT co-antagonist protein RsbRA -
EL050_RS02920 582866..583231 + 366 WP_020450259.1 STAS domain-containing protein -
EL050_RS02925 583234..583635 + 402 WP_020450260.1 anti-sigma regulatory factor -
EL050_RS02930 583646..584653 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
EL050_RS02935 584712..585038 + 327 WP_020450262.1 anti-sigma factor antagonist -
EL050_RS02940 585038..585520 + 483 WP_020450263.1 anti-sigma B factor RsbW -
EL050_RS02945 585486..586277 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
EL050_RS02950 586274..586873 + 600 WP_020450265.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T286935 WP_003179128.1 NZ_LR134165:581567-581917 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT286935 WP_006638778.1 NZ_LR134165:581281-581562 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References