Detailed information of TA system TA028693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 1809675..1810189
• Replicon: chromosome
• Accession: NC_019960
• Organism: Prevotella dentalis DSM 3688

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9D395
• Locus tag: PREDE_RS07145
• Protein ID: WP_005845445.1
• Coordinates: 1809675..1809938 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F9D396
• Locus tag: PREDE_RS07150
• Protein ID: WP_005845447.1
• Coordinates: 1809929..1810189 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PREDE_RS07130	1805563..1807074	-	1512	WP_015298599.1	acetyl-CoA hydrolase	-
PREDE_RS07135	1807437..1808285	-	849	WP_015298600.1	prolipoprotein diacylglyceryl transferase	-
PREDE_RS07140	1808429..1809532	-	1104	WP_005845443.1	redox-regulated ATPase YchF	-
PREDE_RS07145	1809675..1809938	-	264	WP_005845445.1	Txe/YoeB family addiction module toxin	Toxin
PREDE_RS07150	1809929..1810189	-	261	WP_005845447.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PREDE_RS07155	1810428..1811453	+	1026	WP_044126832.1	acyltransferase	-
PREDE_RS13870	1811582..1811756	-	175	Protein_1371	redox-regulated ATPase YchF	-
PREDE_RS07165	1811780..1812061	-	282	WP_005845454.1	virulence protein	-
PREDE_RS07170	1812049..1812243	-	195	WP_005845455.1	hypothetical protein	-
PREDE_RS07175	1812382..1815144	-	2763	WP_005845457.1	DNA polymerase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10362.07 Da
• Isoelectric Point: 10.1580

>T28693 WP_005845445.1 NC_019960:c1809938-1809675 [Prevotella dentalis DSM 3688]
MEIILLKQAQTDLEYWKKSGNKAIMRRITDFLKDISEHPFTGIGKPEPLRFGLVGKWSRRINHEHRIIYSVDESGRLYVY
VLAMRYH

Nucleotide

• Length: 264 bp

>T28693 NC_019960:c1809938-1809675 [Prevotella dentalis DSM 3688]
ATGGAAATAATTCTGCTGAAACAAGCCCAGACCGACCTGGAATATTGGAAGAAGTCGGGTAACAAAGCCATCATGCGACG
CATTACCGACTTCCTGAAAGACATCTCCGAGCATCCCTTTACCGGCATTGGCAAGCCCGAACCTCTTAGATTTGGGCTTG
TCGGGAAATGGTCGCGGCGTATCAACCACGAGCACCGCATCATCTATTCTGTGGACGAAAGCGGCAGGTTGTACGTCTAC
GTATTGGCCATGCGATACCACTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10064.42 Da
• Isoelectric Point: 4.5732

>AT28693 WP_005845447.1 NC_019960:c1810189-1809929 [Prevotella dentalis DSM 3688]
MRTTNYTDLRNNLKGYFDKVVDDCEPLIVHRGDKESVVIISMEEYNAIKETEYIMRSPRMADIIKEGEKEIEQGQGKPVD
LDNLWK

Nucleotide

• Length: 261 bp

>AT28693 NC_019960:c1810189-1809929 [Prevotella dentalis DSM 3688]
ATGAGAACGACAAATTATACAGACCTTAGAAACAACCTGAAAGGGTATTTCGACAAAGTGGTTGACGACTGCGAGCCCCT
GATTGTGCACCGCGGCGATAAGGAGAGCGTGGTGATTATCTCCATGGAGGAGTACAACGCCATCAAGGAAACAGAGTATA
TCATGCGCTCGCCAAGGATGGCAGACATCATTAAGGAGGGCGAAAAAGAGATTGAGCAAGGCCAGGGAAAGCCTGTCGAT
CTGGACAATTTATGGAAATAA

Structures

Toxin

• AlphaFold DB: F9D395

Antitoxin

• AlphaFold DB: F9D396