286927

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2251431..2252170 Replicon chromosome
Accession NZ_LR134164
Organism Enterobacter hormaechei strain NCTC11571

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EL051_RS10885 Protein ID WP_063137753.1
Coordinates 2251431..2251916 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag EL051_RS10890 Protein ID WP_003857131.1
Coordinates 2251904..2252170 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL051_RS10860 2247215..2248114 - 900 WP_023300124.1 LysR family transcriptional regulator -
EL051_RS10865 2248453..2249475 + 1023 WP_126314876.1 alpha/beta hydrolase -
EL051_RS10870 2249571..2250335 + 765 WP_023300126.1 SDR family oxidoreductase -
EL051_RS10875 2250870..2251100 + 231 Protein_2086 DUF4225 domain-containing protein -
EL051_RS10880 2251075..2251413 - 339 WP_126314877.1 hypothetical protein -
EL051_RS10885 2251431..2251916 - 486 WP_063137753.1 GNAT family N-acetyltransferase Toxin
EL051_RS10890 2251904..2252170 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
EL051_RS10895 2252234..2253163 - 930 WP_126314878.1 LysR family transcriptional regulator -
EL051_RS10900 2253293..2254681 + 1389 WP_126314879.1 MFS transporter -
EL051_RS10905 2254660..2255217 - 558 WP_045622668.1 OmpH family outer membrane protein -
EL051_RS10910 2255338..2256474 - 1137 WP_126314880.1 type 1 fimbrial protein -
EL051_RS10915 2256498..2257022 - 525 WP_126315298.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2229743..2252170 22427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17518.18 Da        Isoelectric Point: 9.6275

>T286927 WP_063137753.1 NZ_LR134164:c2251916-2251431 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT286927 WP_003857131.1 NZ_LR134164:c2252170-2251904 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References