286926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1099516..1100137 Replicon chromosome
Accession NZ_LR134164
Organism Enterobacter hormaechei strain NCTC11571

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag EL051_RS05275 Protein ID WP_015571250.1
Coordinates 1099516..1099734 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag EL051_RS05280 Protein ID WP_006809850.1
Coordinates 1099763..1100137 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL051_RS05245 1095528..1095788 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
EL051_RS05250 1095791..1095931 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL051_RS05255 1095928..1096638 - 711 WP_105322505.1 GNAT family N-acetyltransferase -
EL051_RS05260 1096741..1098201 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
EL051_RS05265 1098173..1098640 - 468 WP_126314657.1 hypothetical protein -
EL051_RS05270 1098757..1099308 - 552 WP_023305596.1 maltose O-acetyltransferase -
EL051_RS05275 1099516..1099734 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
EL051_RS05280 1099763..1100137 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
EL051_RS05285 1100647..1103793 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
EL051_RS05290 1103816..1105009 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T286926 WP_015571250.1 NZ_LR134164:c1099734-1099516 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT286926 WP_006809850.1 NZ_LR134164:c1100137-1099763 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References