Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1365773..1366445 Replicon chromosome
Accession NZ_LR134163
Organism Yersinia pseudotuberculosis strain NCTC10217

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag EL027_RS06290 Protein ID WP_012104676.1
Coordinates 1365773..1366198 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag EL027_RS06295 Protein ID WP_002209939.1
Coordinates 1366179..1366445 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL027_RS06270 1361451..1361969 + 519 WP_002209934.1 flavodoxin FldB -
EL027_RS06275 1362054..1363511 - 1458 WP_032466588.1 cell envelope integrity protein CreD -
EL027_RS06280 1363632..1365050 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
EL027_RS06285 1365075..1365773 - 699 WP_002209937.1 two-component system response regulator CreB -
EL027_RS06290 1365773..1366198 - 426 WP_012104676.1 protein YgfX Toxin
EL027_RS06295 1366179..1366445 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
EL027_RS06300 1366762..1367754 + 993 WP_012413924.1 tRNA-modifying protein YgfZ -
EL027_RS06305 1367827..1368324 - 498 WP_002209941.1 DUF2165 family protein -
EL027_RS06310 1368582..1369283 - 702 WP_012413925.1 hemolysin III family protein -
EL027_RS06315 1369485..1370588 - 1104 WP_012413926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T286918 WP_012104676.1 NZ_LR134163:c1366198-1365773 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT286918 WP_002209939.1 NZ_LR134163:c1366445-1366179 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References