Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 340534..341517 Replicon chromosome
Accession NZ_LR134163
Organism Yersinia pseudotuberculosis strain NCTC10217

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL027_RS01525 Protein ID WP_011192520.1
Coordinates 341059..341517 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL027_RS01520 Protein ID WP_002210982.1
Coordinates 340534..340980 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL027_RS01500 336061..336768 + 708 WP_038823925.1 murein tripeptide amidase MpaA -
EL027_RS01505 336810..337790 - 981 WP_012413751.1 L-Ala-D/L-Glu epimerase -
EL027_RS01510 337953..338456 + 504 WP_002210984.1 thiol peroxidase -
EL027_RS01515 338620..340197 - 1578 WP_011192519.1 transcriptional regulator TyrR -
EL027_RS01520 340534..340980 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
EL027_RS01525 341059..341517 + 459 WP_011192520.1 RES family NAD+ phosphorylase Toxin
EL027_RS01530 341527..342588 - 1062 WP_012413752.1 YcjF family protein -
EL027_RS01535 342585..343982 - 1398 WP_012105043.1 YcjX family protein -
EL027_RS01540 343963..344205 - 243 WP_126286833.1 phage shock protein PspD -
EL027_RS01545 344290..344649 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
EL027_RS01550 344649..344876 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
EL027_RS01555 345038..345703 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T286917 WP_011192520.1 NZ_LR134163:341059-341517 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT286917 WP_002210982.1 NZ_LR134163:340534-340980 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q66A68

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References