Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 340534..341517 Replicon chromosome
Accession NZ_LR134163
Organism Yersinia pseudotuberculosis strain NCTC10217

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL027_RS01525 Protein ID WP_011192520.1
Coordinates 341059..341517 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL027_RS01520 Protein ID WP_002210982.1
Coordinates 340534..340980 (+) Length 149 a.a.

Genomic Context

EL027_RS01500EL027_RS01510EL027_RS01520EL027_RS01525EL027_RS01505EL027_RS01515EL027_RS01530EL027_RS01535EL027_RS01540EL027_RS01545EL027_RS01550EL027_RS01555
Location: 336061..336768 (708 bp)
Type: Others
Protein ID: WP_038823925.1
Location: 337953..338456 (504 bp)
Type: Others
Protein ID: WP_002210984.1
Location: 340534..340980 (447 bp)
Type: Antitoxin
Protein ID: WP_002210982.1
Location: 341059..341517 (459 bp)
Type: Toxin
Protein ID: WP_011192520.1
Location: 336810..337790 (981 bp)
Type: Others
Protein ID: WP_012413751.1
Location: 338620..340197 (1578 bp)
Type: Others
Protein ID: WP_011192519.1
Location: 341527..342588 (1062 bp)
Type: Others
Protein ID: WP_012413752.1
Location: 342585..343982 (1398 bp)
Type: Others
Protein ID: WP_012105043.1
Location: 343963..344205 (243 bp)
Type: Others
Protein ID: WP_126286833.1
Location: 344290..344649 (360 bp)
Type: Others
Protein ID: WP_002210977.1
Location: 344649..344876 (228 bp)
Type: Others
Protein ID: WP_002210976.1
Location: 345038..345703 (666 bp)
Type: Others
Protein ID: WP_002210975.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL027_RS01500336061..336768+708WP_038823925.1murein tripeptide amidase MpaA-
EL027_RS01505336810..337790-981WP_012413751.1L-Ala-D/L-Glu epimerase-
EL027_RS01510337953..338456+504WP_002210984.1thiol peroxidase-
EL027_RS01515338620..340197-1578WP_011192519.1transcriptional regulator TyrR-
EL027_RS01520340534..340980+447WP_002210982.1DUF2384 domain-containing proteinAntitoxin
EL027_RS01525341059..341517+459WP_011192520.1RES family NAD+ phosphorylaseToxin
EL027_RS01530341527..342588-1062WP_012413752.1YcjF family protein-
EL027_RS01535342585..343982-1398WP_012105043.1YcjX family protein-
EL027_RS01540343963..344205-243WP_126286833.1phage shock protein PspD-
EL027_RS01545344290..344649-360WP_002210977.1envelope stress response membrane protein PspC-
EL027_RS01550344649..344876-228WP_002210976.1envelope stress response membrane protein PspB-
EL027_RS01555345038..345703-666WP_002210975.1phage shock protein PspA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T286917 WP_011192520.1 NZ_LR134163:341059-341517 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT286917 WP_002210982.1 NZ_LR134163:340534-340980 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ66A68

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E8XFL1

References