Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3597843..3598461 Replicon chromosome
Accession NZ_LR134161
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC13629

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EL026_RS16860 Protein ID WP_002208622.1
Coordinates 3598258..3598461 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag EL026_RS16855 Protein ID WP_005163463.1
Coordinates 3597843..3598211 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL026_RS16820 3593497..3593757 + 261 WP_005163438.1 type B 50S ribosomal protein L31 -
EL026_RS16825 3593773..3593916 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EL026_RS16830 3594044..3594922 - 879 WP_005163442.1 metal ABC transporter substrate-binding protein -
EL026_RS16835 3594985..3595842 - 858 WP_005163445.1 metal ABC transporter permease -
EL026_RS16840 3595856..3596566 - 711 WP_014609124.1 ABC transporter ATP-binding protein -
EL026_RS16850 3597332..3597685 + 354 WP_005163460.1 hypothetical protein -
EL026_RS16855 3597843..3598211 + 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
EL026_RS16860 3598258..3598461 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EL026_RS16870 3599298..3599603 + 306 WP_005163466.1 MGMT family protein -
EL026_RS16875 3599655..3600185 - 531 WP_005163468.1 YbaY family lipoprotein -
EL026_RS16880 3600446..3601309 + 864 WP_005163474.1 acyl-CoA thioesterase II -
EL026_RS16885 3601423..3602712 - 1290 WP_005167660.1 ammonium transporter AmtB -
EL026_RS16890 3602752..3603090 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T286914 WP_002208622.1 NZ_LR134161:3598258-3598461 [Yersinia enterocolitica subsp. enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT286914 WP_005163463.1 NZ_LR134161:3597843-3598211 [Yersinia enterocolitica subsp. enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References