Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1206264..1206936 Replicon chromosome
Accession NZ_LR134161
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC13629

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag EL026_RS05485 Protein ID WP_005166047.1
Coordinates 1206511..1206936 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag EL026_RS05480 Protein ID WP_004390965.1
Coordinates 1206264..1206530 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL026_RS05460 1201879..1202481 - 603 WP_005164134.1 HD domain-containing protein -
EL026_RS05465 1202712..1203395 + 684 WP_005180855.1 hemolysin III family protein -
EL026_RS05470 1203807..1204809 - 1003 Protein_1017 IS110 family transposase -
EL026_RS05475 1205005..1205997 - 993 WP_005166051.1 tRNA-modifying protein YgfZ -
EL026_RS05480 1206264..1206530 + 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
EL026_RS05485 1206511..1206936 + 426 WP_005166047.1 protein YgfX Toxin
EL026_RS05490 1206936..1207634 + 699 WP_005166045.1 two-component system response regulator CreB -
EL026_RS05495 1207645..1209067 + 1423 Protein_1022 two-component system sensor histidine kinase CreC -
EL026_RS05500 1209159..1210580 + 1422 WP_005166043.1 cell envelope integrity protein CreD -
EL026_RS05505 1210639..1211157 - 519 WP_005166042.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T286907 WP_005166047.1 NZ_LR134161:1206511-1206936 [Yersinia enterocolitica subsp. enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT286907 WP_004390965.1 NZ_LR134161:1206264-1206530 [Yersinia enterocolitica subsp. enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References