Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 352765..353408 Replicon chromosome
Accession NZ_LR134161
Organism Yersinia enterocolitica subsp. enterocolitica strain NCTC13629

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag EL026_RS01585 Protein ID WP_005161957.1
Coordinates 352989..353408 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag EL026_RS01580 Protein ID WP_005161959.1
Coordinates 352765..352992 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL026_RS01555 347878..349041 + 1164 WP_005161974.1 mannitol-1-phosphate 5-dehydrogenase -
EL026_RS01560 349273..349827 + 555 WP_005161972.1 MltR family transcriptional regulator -
EL026_RS01565 349824..350435 - 612 WP_016266331.1 LysE family translocator -
EL026_RS01570 350703..352184 + 1482 WP_005161967.1 PLP-dependent aminotransferase family protein -
EL026_RS01575 352277..352633 + 357 WP_005161962.1 YibL family ribosome-associated protein -
EL026_RS01580 352765..352992 + 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL026_RS01585 352989..353408 + 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
EL026_RS01590 353562..354233 - 672 WP_005161954.1 6-N-hydroxylaminopurine resistance protein -
EL026_RS01595 354312..356261 - 1950 WP_005161951.1 methyl-accepting chemotaxis protein -
EL026_RS01600 356585..357208 - 624 WP_005161946.1 superoxide dismutase [Mn] -
EL026_RS01605 357335..358189 - 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T286902 WP_005161957.1 NZ_LR134161:352989-353408 [Yersinia enterocolitica subsp. enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT286902 WP_005161959.1 NZ_LR134161:352765-352992 [Yersinia enterocolitica subsp. enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References