Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3391204..3391876 Replicon chromosome
Accession NZ_LR134160
Organism Yersinia pseudotuberculosis strain NCTC8480

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag EL033_RS15675 Protein ID WP_012104676.1
Coordinates 3391204..3391629 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag EL033_RS15680 Protein ID WP_002209939.1
Coordinates 3391610..3391876 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL033_RS15655 3386882..3387400 + 519 WP_002209934.1 flavodoxin FldB -
EL033_RS15660 3387485..3388942 - 1458 WP_032466588.1 cell envelope integrity protein CreD -
EL033_RS15665 3389063..3390481 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
EL033_RS15670 3390506..3391204 - 699 WP_002209937.1 two-component system response regulator CreB -
EL033_RS15675 3391204..3391629 - 426 WP_012104676.1 protein YgfX Toxin
EL033_RS15680 3391610..3391876 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
EL033_RS15685 3392193..3393185 + 993 WP_012413924.1 tRNA-modifying protein YgfZ -
EL033_RS15690 3393258..3393755 - 498 WP_002209941.1 DUF2165 family protein -
EL033_RS15695 3394013..3394714 - 702 WP_012413925.1 hemolysin III family protein -
EL033_RS15700 3394916..3396019 - 1104 WP_012413926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T286900 WP_012104676.1 NZ_LR134160:c3391629-3391204 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT286900 WP_002209939.1 NZ_LR134160:c3391876-3391610 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References