Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2368664..2369647 Replicon chromosome
Accession NZ_LR134160
Organism Yersinia pseudotuberculosis strain NCTC8480

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL033_RS10930 Protein ID WP_011192520.1
Coordinates 2369189..2369647 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL033_RS10925 Protein ID WP_002210982.1
Coordinates 2368664..2369110 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL033_RS10905 2364191..2364898 + 708 WP_038823925.1 murein tripeptide amidase MpaA -
EL033_RS10910 2364940..2365920 - 981 WP_012413751.1 L-Ala-D/L-Glu epimerase -
EL033_RS10915 2366083..2366586 + 504 WP_002210984.1 thiol peroxidase -
EL033_RS10920 2366750..2368327 - 1578 WP_011192519.1 transcriptional regulator TyrR -
EL033_RS10925 2368664..2369110 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
EL033_RS10930 2369189..2369647 + 459 WP_011192520.1 RES family NAD+ phosphorylase Toxin
EL033_RS10935 2369657..2370718 - 1062 WP_012413752.1 YcjF family protein -
EL033_RS10940 2370715..2372112 - 1398 WP_012105043.1 YcjX family protein -
EL033_RS10945 2372093..2372335 - 243 WP_002216375.1 phage shock protein PspD -
EL033_RS10950 2372420..2372779 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
EL033_RS10955 2372779..2373006 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
EL033_RS10960 2373168..2373833 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T286899 WP_011192520.1 NZ_LR134160:2369189-2369647 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT286899 WP_002210982.1 NZ_LR134160:2368664-2369110 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q66A68

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References