Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2368664..2369647 Replicon chromosome
Accession NZ_LR134160
Organism Yersinia pseudotuberculosis strain NCTC8480

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL033_RS10930 Protein ID WP_011192520.1
Coordinates 2369189..2369647 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL033_RS10925 Protein ID WP_002210982.1
Coordinates 2368664..2369110 (+) Length 149 a.a.

Genomic Context

EL033_RS10905EL033_RS10915EL033_RS10925EL033_RS10930EL033_RS10910EL033_RS10920EL033_RS10935EL033_RS10940EL033_RS10945EL033_RS10950EL033_RS10955EL033_RS10960
Location: 2364191..2364898 (708 bp)
Type: Others
Protein ID: WP_038823925.1
Location: 2366083..2366586 (504 bp)
Type: Others
Protein ID: WP_002210984.1
Location: 2368664..2369110 (447 bp)
Type: Antitoxin
Protein ID: WP_002210982.1
Location: 2369189..2369647 (459 bp)
Type: Toxin
Protein ID: WP_011192520.1
Location: 2364940..2365920 (981 bp)
Type: Others
Protein ID: WP_012413751.1
Location: 2366750..2368327 (1578 bp)
Type: Others
Protein ID: WP_011192519.1
Location: 2369657..2370718 (1062 bp)
Type: Others
Protein ID: WP_012413752.1
Location: 2370715..2372112 (1398 bp)
Type: Others
Protein ID: WP_012105043.1
Location: 2372093..2372335 (243 bp)
Type: Others
Protein ID: WP_002216375.1
Location: 2372420..2372779 (360 bp)
Type: Others
Protein ID: WP_002210977.1
Location: 2372779..2373006 (228 bp)
Type: Others
Protein ID: WP_002210976.1
Location: 2373168..2373833 (666 bp)
Type: Others
Protein ID: WP_002210975.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL033_RS109052364191..2364898+708WP_038823925.1murein tripeptide amidase MpaA-
EL033_RS109102364940..2365920-981WP_012413751.1L-Ala-D/L-Glu epimerase-
EL033_RS109152366083..2366586+504WP_002210984.1thiol peroxidase-
EL033_RS109202366750..2368327-1578WP_011192519.1transcriptional regulator TyrR-
EL033_RS109252368664..2369110+447WP_002210982.1DUF2384 domain-containing proteinAntitoxin
EL033_RS109302369189..2369647+459WP_011192520.1RES family NAD+ phosphorylaseToxin
EL033_RS109352369657..2370718-1062WP_012413752.1YcjF family protein-
EL033_RS109402370715..2372112-1398WP_012105043.1YcjX family protein-
EL033_RS109452372093..2372335-243WP_002216375.1phage shock protein PspD-
EL033_RS109502372420..2372779-360WP_002210977.1envelope stress response membrane protein PspC-
EL033_RS109552372779..2373006-228WP_002210976.1envelope stress response membrane protein PspB-
EL033_RS109602373168..2373833-666WP_002210975.1phage shock protein PspA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T286899 WP_011192520.1 NZ_LR134160:2369189-2369647 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT286899 WP_002210982.1 NZ_LR134160:2368664-2369110 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ66A68

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E8XFL1

References