Detailed information of TA system TA286890

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3624278..3624984
• Replicon: chromosome
• Accession: NZ_LR134152
• Organism: Escherichia coli strain NCTC9104

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: EL040_RS17690
• Protein ID: WP_072186048.1
• Coordinates: 3624278..3624646 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: EL040_RS17695
• Protein ID: WP_054622944.1
• Coordinates: 3624667..3624984 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL040_RS17675	3621348..3622304	+	957	WP_000121359.1	molybdenum cofactor insertion chaperone PaoD	-
EL040_RS17680	3622481..3623658	+	1178	WP_085968792.1	IS3 family transposase	-
EL040_RS17685	3623667..3623954	+	288	Protein_3442	LysR family transcriptional regulator	-
EL040_RS17690	3624278..3624646	-	369	WP_072186048.1	TA system toxin CbtA family protein	Toxin
EL040_RS17695	3624667..3624984	-	318	WP_054622944.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EL040_RS17700	3625003..3625224	-	222	WP_054622945.1	DUF987 domain-containing protein	-
EL040_RS17705	3625233..3625709	-	477	WP_001548163.1	RadC family protein	-
EL040_RS17710	3625725..3626186	-	462	WP_054622946.1	antirestriction protein	-
EL040_RS17715	3626200..3626391	-	192	Protein_3448	DUF905 domain-containing protein	-
EL040_RS17725	3627957..3628838	-	882	WP_054622947.1	LysR family transcriptional regulator	-
EL040_RS17730	3628835..3629527	-	693	WP_032230813.1	gamma-glutamylcyclotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3622283..3627821	5538
	-	inside	IScluster/Tn	-	-	3622481..3627605	5124

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13824.00 Da
• Isoelectric Point: 8.2905

>T286890 WP_072186048.1 NZ_LR134152:c3624646-3624278 [Escherichia coli]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFWDQTVIQEHIDAGITLANVVNFLVEKHELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11824.47 Da
• Isoelectric Point: 6.9459

>AT286890 WP_054622944.1 NZ_LR134152:c3624984-3624667 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp