Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3624278..3624984 Replicon chromosome
Accession NZ_LR134152
Organism Escherichia coli strain NCTC9104

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag EL040_RS17690 Protein ID WP_072186048.1
Coordinates 3624278..3624646 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EL040_RS17695 Protein ID WP_054622944.1
Coordinates 3624667..3624984 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL040_RS17675 3621348..3622304 + 957 WP_000121359.1 molybdenum cofactor insertion chaperone PaoD -
EL040_RS17680 3622481..3623658 + 1178 WP_085968792.1 IS3 family transposase -
EL040_RS17685 3623667..3623954 + 288 Protein_3442 LysR family transcriptional regulator -
EL040_RS17690 3624278..3624646 - 369 WP_072186048.1 TA system toxin CbtA family protein Toxin
EL040_RS17695 3624667..3624984 - 318 WP_054622944.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL040_RS17700 3625003..3625224 - 222 WP_054622945.1 DUF987 domain-containing protein -
EL040_RS17705 3625233..3625709 - 477 WP_001548163.1 RadC family protein -
EL040_RS17710 3625725..3626186 - 462 WP_054622946.1 antirestriction protein -
EL040_RS17715 3626200..3626391 - 192 Protein_3448 DUF905 domain-containing protein -
EL040_RS17725 3627957..3628838 - 882 WP_054622947.1 LysR family transcriptional regulator -
EL040_RS17730 3628835..3629527 - 693 WP_032230813.1 gamma-glutamylcyclotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3622283..3627821 5538
- inside IScluster/Tn - - 3622481..3627605 5124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13824.00 Da        Isoelectric Point: 8.2905

>T286890 WP_072186048.1 NZ_LR134152:c3624646-3624278 [Escherichia coli]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFWDQTVIQEHIDAGITLANVVNFLVEKHELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11824.47 Da        Isoelectric Point: 6.9459

>AT286890 WP_054622944.1 NZ_LR134152:c3624984-3624667 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References