Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 545624..547247 Replicon chromosome
Accession NZ_LR134151
Organism Serratia plymuthica strain NCTC8900

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL066_RS02595 Protein ID WP_126479981.1
Coordinates 545925..547247 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL066_RS02590 Protein ID WP_126479979.1
Coordinates 545624..545920 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL066_RS02565 541364..542434 + 1071 WP_126479976.1 LPS export ABC transporter permease LptG -
EL066_RS02575 543027..543422 + 396 WP_119804576.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
EL066_RS02580 543415..544365 + 951 WP_126479978.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
EL066_RS02585 544781..545416 + 636 WP_065505838.1 carbonic anhydrase -
EL066_RS02590 545624..545920 + 297 WP_126479979.1 helix-turn-helix transcriptional regulator Antitoxin
EL066_RS02595 545925..547247 + 1323 WP_126479981.1 type II toxin-antitoxin system HipA family toxin Toxin
EL066_RS02600 547416..548366 + 951 WP_126479983.1 toll/interleukin-1 receptor domain-containing protein -
EL066_RS02605 548526..549611 - 1086 WP_126479985.1 hypothetical protein -
EL066_RS02610 549614..549871 - 258 WP_126479987.1 helix-turn-helix transcriptional regulator -
EL066_RS02615 549935..551029 + 1095 WP_126486233.1 DNA cytosine methyltransferase -
EL066_RS02620 551167..551472 - 306 WP_126486235.1 hypothetical protein -
EL066_RS02625 551515..551607 - 93 Protein_494 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50128.11 Da        Isoelectric Point: 6.3191

>T286859 WP_126479981.1 NZ_LR134151:545925-547247 [Serratia plymuthica]
MRRSQQRLAIWMNGIPVGYWEKHKGEDRLEYHPDWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRFHAESLDPFDLLAELGRDCVGAIQLLDIDEQPTHIFSIRQRPLSEAQIAEMLRNTATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDGQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEVLSRSDQAETDRRHFFKAQIIFWLLVATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKQGEITGLGQQEIESIIEELL
AETPGVIERITRLLSDSFPPELAACIFDGIRQQCARLEGR

Download         Length: 1323 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10997.52 Da        Isoelectric Point: 8.0099

>AT286859 WP_126479979.1 NZ_LR134151:545624-545920 [Serratia plymuthica]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEMVLSSELTSPGCE
TEDTSTTHIDSPARREQW

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References