Detailed information of TA system TA286858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 543027..544365
• Replicon: chromosome
• Accession: NZ_LR134151
• Organism: Serratia plymuthica strain NCTC8900

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: EL066_RS02580
• Protein ID: WP_126479978.1
• Coordinates: 543415..544365 (+)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: EL066_RS02575
• Protein ID: WP_119804576.1
• Coordinates: 543027..543422 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL066_RS02555	538476..539987	-	1512	WP_126479972.1	leucyl aminopeptidase	-
EL066_RS02560	540270..541364	+	1095	WP_126479974.1	LPS export ABC transporter permease LptF	-
EL066_RS02565	541364..542434	+	1071	WP_126479976.1	LPS export ABC transporter permease LptG	-
EL066_RS02575	543027..543422	+	396	WP_119804576.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EL066_RS02580	543415..544365	+	951	WP_126479978.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL066_RS02585	544781..545416	+	636	WP_065505838.1	carbonic anhydrase	-
EL066_RS02590	545624..545920	+	297	WP_126479979.1	helix-turn-helix transcriptional regulator	-
EL066_RS02595	545925..547247	+	1323	WP_126479981.1	type II toxin-antitoxin system HipA family toxin	-
EL066_RS02600	547416..548366	+	951	WP_126479983.1	toll/interleukin-1 receptor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-301)

Antitoxin

• Protein of unknown function DUF6088 (7-125)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 35821.06 Da
• Isoelectric Point: 4.5337

>T286858 WP_126479978.1 NZ_LR134151:543415-544365 [Serratia plymuthica]
MDDLTTLFPDVADALGIESVAIVEKDYYIVELLRLLQPLVFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPAAGFSQ
QYSRGQRKNIRKGIIQTIIETIAASGTFRLDEEYPKVTRDEYRYNEIPVRYPQEYAQIPCLRPFIKLELMETDLLEVAEN
RAISSLVMDLTKKGEVVGAFPCATITSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGSDVPVLKHLV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESQVSWGEAYTCFRKTALDVVDA

Nucleotide

• Length: 951 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14405.69 Da
• Isoelectric Point: 10.9938

>AT286858 WP_119804576.1 NZ_LR134151:543027-543422 [Serratia plymuthica]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLNVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGNSKLNG

Nucleotide

• Length: 396 bp