286851

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2088512..2089041 Replicon chromosome
Accession NZ_LR134139
Organism Staphylococcus aureus strain NCTC4163

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ELZ55_RS10865 Protein ID WP_000621175.1
Coordinates 2088512..2088874 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag ELZ55_RS10870 Protein ID WP_000948331.1
Coordinates 2088871..2089041 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ55_RS10840 2085490..2086260 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
ELZ55_RS10845 2086235..2086714 - 480 WP_001190829.1 anti-sigma B factor RsbW -
ELZ55_RS10850 2086716..2087042 - 327 WP_001052491.1 anti-sigma factor antagonist -
ELZ55_RS10855 2087161..2088162 - 1002 WP_042727554.1 PP2C family protein-serine/threonine phosphatase -
ELZ55_RS10865 2088512..2088874 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ELZ55_RS10870 2088871..2089041 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ELZ55_RS10875 2089126..2090274 - 1149 WP_001281154.1 alanine racemase -
ELZ55_RS10880 2090340..2090699 - 360 WP_000581197.1 holo-ACP synthase -
ELZ55_RS10885 2090703..2091194 - 492 WP_001205912.1 PH domain-containing protein -
ELZ55_RS10890 2091181..2092764 - 1584 WP_001294620.1 PH domain-containing protein -
ELZ55_RS10895 2092757..2093236 - 480 WP_001287079.1 hypothetical protein -
ELZ55_RS10900 2093445..2094005 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T286851 WP_000621175.1 NZ_LR134139:c2088874-2088512 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT286851 WP_000948331.1 NZ_LR134139:c2089041-2088871 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References