Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1896803..1897331 | Replicon | chromosome |
| Accession | NC_019955 | ||
| Organism | Vibrio parahaemolyticus BB22OP | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | K5TRR0 |
| Locus tag | VPBB_RS08650 | Protein ID | WP_005377002.1 |
| Coordinates | 1897041..1897331 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | VPBB_RS08645 | Protein ID | WP_005377003.1 |
| Coordinates | 1896803..1897051 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VPBB_RS08615 | 1892783..1893220 | - | 438 | WP_029826736.1 | hypothetical protein | - |
| VPBB_RS08620 | 1893391..1893732 | - | 342 | WP_029826738.1 | hypothetical protein | - |
| VPBB_RS23905 | 1894385..1894474 | - | 90 | WP_072829120.1 | DUF3265 domain-containing protein | - |
| VPBB_RS25725 | 1894603..1894962 | + | 360 | WP_154218374.1 | hypothetical protein | - |
| VPBB_RS23910 | 1895484..1895630 | - | 147 | WP_072829176.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08635 | 1895591..1895944 | - | 354 | WP_015296924.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| VPBB_RS23915 | 1895973..1896065 | - | 93 | WP_004748931.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08640 | 1896091..1896606 | - | 516 | WP_029849319.1 | hypothetical protein | - |
| VPBB_RS08645 | 1896803..1897051 | + | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VPBB_RS08650 | 1897041..1897331 | + | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VPBB_RS23920 | 1897350..1897460 | - | 111 | WP_071816346.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08655 | 1897463..1898242 | - | 780 | WP_015296925.1 | HK97 family phage prohead protease | - |
| VPBB_RS08660 | 1898384..1899355 | - | 972 | Protein_1715 | phosphotransferase | - |
| VPBB_RS08665 | 1899498..1899956 | - | 459 | WP_029849324.1 | hypothetical protein | - |
| VPBB_RS23925 | 1899985..1900074 | - | 90 | WP_072829120.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08670 | 1900762..1901010 | + | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VPBB_RS08675 | 1901000..1901290 | + | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VPBB_RS08680 | 1901422..1901874 | - | 453 | WP_015296928.1 | hypothetical protein | - |
| VPBB_RS23930 | 1901901..1901993 | - | 93 | WP_072859724.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1848183..1912758 | 64575 | |
| - | inside | Integron | - | - | 1888259..1911047 | 22788 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11261.25 Da Isoelectric Point: 10.5932
>T28685 WP_005377002.1 NC_019955:1897041-1897331 [Vibrio parahaemolyticus BB22OP]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T28685 NC_019955:1897041-1897331 [Vibrio parahaemolyticus BB22OP]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT28685 WP_005377003.1 NC_019955:1896803-1897051 [Vibrio parahaemolyticus BB22OP]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT28685 NC_019955:1896803-1897051 [Vibrio parahaemolyticus BB22OP]
ATGACCACTAGAATTTTAGCTGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
ATGACCACTAGAATTTTAGCTGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR02 |