286847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1886022..1886798 Replicon chromosome
Accession NZ_LR134139
Organism Staphylococcus aureus strain NCTC4163

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag ELZ55_RS09540 Protein ID WP_000031108.1
Coordinates 1886022..1886174 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag ELZ55_RS09545 Protein ID WP_001251224.1
Coordinates 1886199..1886798 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELZ55_RS09520 1882229..1883050 + 822 WP_042727629.1 RluA family pseudouridine synthase -
ELZ55_RS09525 1883502..1884887 - 1386 WP_000116229.1 class II fumarate hydratase -
ELZ55_RS09530 1885083..1885478 - 396 WP_000901023.1 hypothetical protein -
ELZ55_RS09540 1886022..1886174 - 153 WP_000031108.1 hypothetical protein Toxin
ELZ55_RS09545 1886199..1886798 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
ELZ55_RS09550 1886957..1887427 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
ELZ55_RS09555 1887432..1888559 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
ELZ55_RS09560 1888711..1889433 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
ELZ55_RS09565 1889426..1890883 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1891182..1892501 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T286847 WP_000031108.1 NZ_LR134139:c1886174-1886022 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT286847 WP_001251224.1 NZ_LR134139:c1886798-1886199 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References