Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2310911..2311529 Replicon chromosome
Accession NZ_LR134138
Organism Kluyvera intermedia strain NCTC12125

Toxin (Protein)


Gene name Hha Uniprot ID A0A447MKF0
Locus tag EL028_RS11375 Protein ID WP_062773821.1
Coordinates 2311311..2311529 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag EL028_RS11370 Protein ID WP_062773820.1
Coordinates 2310911..2311285 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL028_RS11360 2305995..2307191 + 1197 WP_062773816.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL028_RS11365 2307214..2310361 + 3148 Protein_2203 multidrug efflux RND transporter permease subunit AcrB -
EL028_RS11370 2310911..2311285 + 375 WP_062773820.1 Hha toxicity modulator TomB Antitoxin
EL028_RS11375 2311311..2311529 + 219 WP_062773821.1 hemolysin expression modulator Hha Toxin
EL028_RS11380 2311670..2312224 + 555 WP_062773823.1 maltose O-acetyltransferase -
EL028_RS11385 2312328..2312798 + 471 WP_062774064.1 YlaC family protein -
EL028_RS11390 2312773..2314218 - 1446 WP_062773825.1 PLP-dependent aminotransferase family protein -
EL028_RS11395 2314321..2315031 + 711 WP_062773826.1 GNAT family N-acetyltransferase -
EL028_RS11400 2315028..2315168 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL028_RS11405 2315168..2315431 - 264 WP_052283831.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.01 Da        Isoelectric Point: 8.9008

>T286843 WP_062773821.1 NZ_LR134138:2311311-2311529 [Kluyvera intermedia]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPTVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14311.05 Da        Isoelectric Point: 4.8887

>AT286843 WP_062773820.1 NZ_LR134138:2310911-2311285 [Kluyvera intermedia]
MDEYSPKRHDIAQLKFLCETLYHDSLATLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYSEDNKLIAQIDEYL
DDTFMLFGNYGVNSDDLQKWRKSGNKLFRCFVNASRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447MKF0

Antitoxin

Source ID Structure

References