Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1877769..1878316 | Replicon | chromosome |
| Accession | NC_019955 | ||
| Organism | Vibrio parahaemolyticus BB22OP | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | VPBB_RS08520 | Protein ID | WP_015296906.1 |
| Coordinates | 1877769..1878071 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A7Y3ZEQ4 |
| Locus tag | VPBB_RS08525 | Protein ID | WP_015296907.1 |
| Coordinates | 1878059..1878316 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VPBB_RS23810 | 1872875..1872991 | - | 117 | WP_140362817.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08490 | 1872982..1873878 | - | 897 | WP_015296901.1 | hypothetical protein | - |
| VPBB_RS23815 | 1873911..1874020 | - | 110 | Protein_1668 | DUF3265 domain-containing protein | - |
| VPBB_RS08495 | 1874025..1874522 | - | 498 | WP_029826770.1 | hypothetical protein | - |
| VPBB_RS23820 | 1874534..1874671 | - | 138 | WP_140362818.1 | DUF3265 domain-containing protein | - |
| VPBB_RS23825 | 1875039..1875131 | - | 93 | WP_072847706.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08505 | 1875159..1875446 | - | 288 | WP_015296903.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VPBB_RS08510 | 1875443..1875724 | - | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VPBB_RS08515 | 1875924..1876508 | - | 585 | WP_025787257.1 | hypothetical protein | - |
| VPBB_RS23830 | 1876535..1876666 | - | 132 | WP_079757871.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08520 | 1877769..1878071 | - | 303 | WP_015296906.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VPBB_RS08525 | 1878059..1878316 | - | 258 | WP_015296907.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VPBB_RS08530 | 1878507..1879139 | - | 633 | WP_029826615.1 | peptidase M15 | - |
| VPBB_RS08535 | 1879307..1879762 | - | 456 | WP_029826614.1 | GNAT family N-acetyltransferase | - |
| VPBB_RS23840 | 1879772..1879891 | - | 120 | WP_071652258.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08540 | 1879878..1880360 | - | 483 | WP_015296910.1 | hypothetical protein | - |
| VPBB_RS08545 | 1880522..1881586 | - | 1065 | WP_015296911.1 | hypothetical protein | - |
| VPBB_RS23845 | 1881615..1881704 | - | 90 | WP_072829136.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08550 | 1881722..1882147 | - | 426 | WP_029826613.1 | N-acetyltransferase | - |
| VPBB_RS23850 | 1882195..1882284 | - | 90 | WP_072829140.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08555 | 1882366..1882656 | - | 291 | WP_025787412.1 | TM2 domain-containing protein | - |
| VPBB_RS23855 | 1882802..1882933 | - | 132 | WP_079757880.1 | DUF3265 domain-containing protein | - |
| VPBB_RS25795 | 1883013..1883192 | - | 180 | WP_041170545.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1848183..1912758 | 64575 | |
| - | inside | Integron | - | - | 1853353..1882656 | 29303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11727.61 Da Isoelectric Point: 4.8838
>T28684 WP_015296906.1 NC_019955:c1878071-1877769 [Vibrio parahaemolyticus BB22OP]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDDDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDDDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T28684 NC_019955:c1878071-1877769 [Vibrio parahaemolyticus BB22OP]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTTGTTAATCCATGTCGTGTTTTCTATAAACAAGACGATGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTTGTTAATCCATGTCGTGTTTTCTATAAACAAGACGATGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9638.16 Da Isoelectric Point: 6.7269
>AT28684 WP_015296907.1 NC_019955:c1878316-1878059 [Vibrio parahaemolyticus BB22OP]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKMVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKMVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT28684 NC_019955:c1878316-1878059 [Vibrio parahaemolyticus BB22OP]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAATGGTGAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAATGGTGAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|