Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3691972..3692638 Replicon chromosome
Accession NZ_LR134136
Organism Atlantibacter hermannii strain NCTC12129

Toxin (Protein)


Gene name cptA Uniprot ID A0A447LT15
Locus tag EL032_RS17625 Protein ID WP_040459615.1
Coordinates 3691972..3692391 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H5V069
Locus tag EL032_RS17630 Protein ID WP_002434469.1
Coordinates 3692372..3692638 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL032_RS17605 (NCTC12129_04079) 3687952..3689686 - 1735 Protein_3475 single-stranded-DNA-specific exonuclease RecJ -
EL032_RS17610 3689690..3690417 - 728 Protein_3476 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL032_RS17615 3690443..3691345 - 903 Protein_3477 site-specific tyrosine recombinase XerD -
EL032_RS17620 (NCTC12129_04083) 3691447..3691968 + 522 WP_002434473.1 flavodoxin FldB -
EL032_RS17625 (NCTC12129_04084) 3691972..3692391 - 420 WP_040459615.1 protein YgfX Toxin
EL032_RS17630 (NCTC12129_04085) 3692372..3692638 - 267 WP_002434469.1 FAD assembly factor SdhE Antitoxin
EL032_RS17635 (NCTC12129_04086) 3692897..3693883 + 987 WP_002434467.1 tRNA-modifying protein YgfZ -
EL032_RS17640 (NCTC12129_04087) 3694041..3694700 - 660 WP_002434465.1 hemolysin III family protein -
EL032_RS17645 (NCTC12129_04088) 3694830..3695141 - 312 WP_002434462.1 N(4)-acetylcytidine aminohydrolase -
EL032_RS17650 (NCTC12129_04089) 3695254..3695991 + 738 WP_002434460.1 MurR/RpiR family transcriptional regulator -
EL032_RS17655 (NCTC12129_04090) 3696118..3697551 + 1434 WP_002434459.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16511.44 Da        Isoelectric Point: 10.5604

>T286838 WP_040459615.1 NZ_LR134136:c3692391-3691972 [Atlantibacter hermannii]
VVLWQSDLRVSWRAQWFSLMLHGIVAAIILLLPWPLSYMPLWLILLSLVVFDCVRSQRRIHSLQGEVKLTIDYRLRWQGI
EWELTAAPWMLQSGMLLRLRHPDTHRSQHLWLAADSMDAGEWRDLRRILMQQPQSGRHP

Download         Length: 420 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10549.05 Da        Isoelectric Point: 5.6178

>AT286838 WP_002434469.1 NZ_LR134136:c3692638-3692372 [Atlantibacter hermannii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRVFIRLLECDDPDLFNWLMNHGKPADSELQRMVQMIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447LT15

Antitoxin

Source ID Structure
AlphaFold DB H5V069

References