Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1186027..1186648 Replicon chromosome
Accession NZ_LR134136
Organism Atlantibacter hermannii strain NCTC12129

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL032_RS05595 Protein ID WP_001291435.1
Coordinates 1186027..1186245 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H5UYE1
Locus tag EL032_RS05600 Protein ID WP_002463720.1
Coordinates 1186274..1186648 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL032_RS05560 (NCTC12129_01266) 1181494..1181874 + 381 WP_040459530.1 hypothetical protein -
EL032_RS05565 (NCTC12129_01267) 1182247..1182498 + 252 WP_002463729.1 hypothetical protein -
EL032_RS05570 (NCTC12129_01268) 1182495..1182713 + 219 WP_002463728.1 hypothetical protein -
EL032_RS05575 1182852..1184404 - 1553 Protein_1091 EAL domain-containing protein -
EL032_RS05580 (NCTC12129_01271) 1184659..1184919 + 261 WP_002463724.1 type B 50S ribosomal protein L31 -
EL032_RS05585 (NCTC12129_01272) 1184922..1185062 + 141 WP_061708247.1 type B 50S ribosomal protein L36 -
EL032_RS05590 (NCTC12129_01273) 1185098..1185564 - 467 Protein_1094 YlaC family protein -
EL032_RS05595 (NCTC12129_01275) 1186027..1186245 - 219 WP_001291435.1 HHA domain-containing protein Toxin
EL032_RS05600 (NCTC12129_01276) 1186274..1186648 - 375 WP_002463720.1 Hha toxicity modulator TomB Antitoxin
EL032_RS22090 (NCTC12129_01277) 1187121..1187933 - 813 WP_284515304.1 efflux RND transporter permease subunit -
EL032_RS05605 (NCTC12129_01278) 1188005..1190275 - 2271 WP_284515254.1 efflux RND transporter permease subunit -
EL032_RS05610 (NCTC12129_01279) 1190298..1191494 - 1197 WP_002463714.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T286831 WP_001291435.1 NZ_LR134136:c1186245-1186027 [Atlantibacter hermannii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.16 Da        Isoelectric Point: 5.1259

>AT286831 WP_002463720.1 NZ_LR134136:c1186648-1186274 [Atlantibacter hermannii]
MDEYSPKRHDIAQLKFLCENLYHDCLLTLGDSNHGWVNDPTSAINLQLNELIEHIASFALNYKIKHDEDNALIEHVDEYL
DDTFMLFSNYGISAQDLQKWRKSGNRLFRCFVNVSKANPVSLSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB H5UYE1

References