Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2501289..2501961 Replicon chromosome
Accession NZ_LR134117
Organism Serratia odorifera strain NCTC11214

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S5D7F3
Locus tag EL065_RS12170 Protein ID WP_039991778.1
Coordinates 2501536..2501961 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4E228
Locus tag EL065_RS12165 Protein ID WP_004959027.1
Coordinates 2501289..2501555 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL065_RS12140 2496357..2497676 + 1320 WP_004959017.1 MHS family MFS transporter -
EL065_RS12145 2497791..2498399 - 609 WP_004959018.1 HD domain-containing protein -
EL065_RS12150 2498594..2499268 + 675 WP_039992574.1 hemolysin III family protein -
EL065_RS12155 2499422..2499922 + 501 WP_004959022.1 DUF2165 domain-containing protein -
EL065_RS12160 2499977..2500966 - 990 WP_004959025.1 tRNA-modifying protein YgfZ -
EL065_RS12165 2501289..2501555 + 267 WP_004959027.1 FAD assembly factor SdhE Antitoxin
EL065_RS12170 2501536..2501961 + 426 WP_039991778.1 membrane protein Toxin
EL065_RS12175 2501961..2502656 + 696 WP_004959031.1 two-component system response regulator CreB -
EL065_RS12180 2502653..2504092 + 1440 WP_004959033.1 two-component system sensor histidine kinase CreC -
EL065_RS12185 2504156..2505485 + 1330 Protein_2351 cell envelope integrity protein CreD -
EL065_RS12190 2505526..2506044 - 519 WP_004959039.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16522.38 Da        Isoelectric Point: 10.9205

>T286824 WP_039991778.1 NZ_LR134117:2501536-2501961 [Serratia odorifera]
VAQWRCNVRISWRTQIVSLLAHGALILLILISPWPEGYGPLWLVLLTLVVFECIRSQKRIATRQGELRVLSAPRHVVWDG
QEWRVIGRPWMPRFGILFTLEPLDGQKRRRLWLASDCMSKADWRQLRQRLSFPPEDDSEAP

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10475.99 Da        Isoelectric Point: 4.8186

>AT286824 WP_004959027.1 NZ_LR134117:2501289-2501555 [Serratia odorifera]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDKDKALFIRLLECDDPDLFNWLMNHGAPQDDELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5D7F3

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4EAY2

References