Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1865422..1865971 | Replicon | chromosome |
| Accession | NC_019955 | ||
| Organism | Vibrio parahaemolyticus BB22OP | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A2K7SRW8 |
| Locus tag | VPBB_RS08430 | Protein ID | WP_015296889.1 |
| Coordinates | 1865672..1865971 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | VPBB_RS08425 | Protein ID | WP_015296888.1 |
| Coordinates | 1865422..1865664 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VPBB_RS08405 | 1860829..1861317 | - | 489 | WP_020840814.1 | hypothetical protein | - |
| VPBB_RS23740 | 1861837..1861929 | - | 93 | WP_079771126.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08410 | 1861953..1863461 | - | 1509 | WP_015296885.1 | ATP-binding protein | - |
| VPBB_RS23745 | 1863627..1863698 | - | 72 | WP_078511467.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08415 | 1863713..1864261 | - | 549 | WP_015296886.1 | hypothetical protein | - |
| VPBB_RS23750 | 1864307..1864417 | - | 111 | WP_140362832.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08420 | 1864414..1865178 | - | 765 | WP_015296887.1 | hypothetical protein | - |
| VPBB_RS23755 | 1865221..1865347 | - | 127 | Protein_1644 | DUF3265 domain-containing protein | - |
| VPBB_RS08425 | 1865422..1865664 | + | 243 | WP_015296888.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VPBB_RS08430 | 1865672..1865971 | + | 300 | WP_015296889.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VPBB_RS23760 | 1866523..1866663 | - | 141 | WP_072612514.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08435 | 1866641..1866925 | - | 285 | WP_013571627.1 | nucleotide pyrophosphohydrolase | - |
| VPBB_RS08440 | 1867082..1867519 | - | 438 | WP_029826846.1 | GIY-YIG nuclease family protein | - |
| VPBB_RS23765 | 1867545..1867703 | - | 159 | WP_079757879.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08445 | 1867652..1868089 | - | 438 | WP_029826865.1 | hypothetical protein | - |
| VPBB_RS23770 | 1868122..1868214 | - | 93 | WP_072829098.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08450 | 1868240..1868524 | - | 285 | WP_015296893.1 | hypothetical protein | - |
| VPBB_RS25910 | 1868569..1868658 | - | 90 | WP_072847691.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08455 | 1868789..1869019 | + | 231 | WP_015296894.1 | DUF2188 domain-containing protein | - |
| VPBB_RS25785 | 1869085..1869252 | - | 168 | WP_140362829.1 | DUF3265 domain-containing protein | - |
| VPBB_RS08465 | 1869634..1869993 | - | 360 | WP_029826751.1 | hypothetical protein | - |
| VPBB_RS25915 | 1870020..1870109 | - | 90 | WP_072832911.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1848183..1912758 | 64575 | |
| - | inside | Integron | - | - | 1853353..1882656 | 29303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11502.11 Da Isoelectric Point: 9.3224
>T28682 WP_015296889.1 NC_019955:1865672-1865971 [Vibrio parahaemolyticus BB22OP]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK
Download Length: 300 bp
>T28682 NC_019955:1865672-1865971 [Vibrio parahaemolyticus BB22OP]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9009.25 Da Isoelectric Point: 5.0914
>AT28682 WP_015296888.1 NC_019955:1865422-1865664 [Vibrio parahaemolyticus BB22OP]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKLCFKSAKEDLNNGNTVDGDSFLNSL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKLCFKSAKEDLNNGNTVDGDSFLNSL
Download Length: 243 bp
>AT28682 NC_019955:1865422-1865664 [Vibrio parahaemolyticus BB22OP]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACTCTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGATAGCTTTCTAAATTCGCTG
TAA
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACTCTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGATAGCTTTCTAAATTCGCTG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|