Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 30136..30761 Replicon chromosome
Accession NZ_LR134117
Organism Serratia odorifera strain NCTC11214

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL065_RS00170 Protein ID WP_004966176.1
Coordinates 30363..30761 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D4EA25
Locus tag EL065_RS00165 Protein ID WP_004966175.1
Coordinates 30136..30363 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL065_RS00165 30136..30363 + 228 WP_004966175.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL065_RS00170 30363..30761 + 399 WP_004966176.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL065_RS00175 30820..31500 - 681 WP_004966177.1 relaxase domain-containing protein -
EL065_RS00180 31586..33853 - 2268 WP_004966178.1 type IV conjugative transfer system coupling protein TraD -
EL065_RS00185 33843..34052 - 210 WP_039992934.1 hypothetical protein -
EL065_RS00190 34054..34584 - 531 WP_004966180.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gtrB 28996..266260 237264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14781.05 Da        Isoelectric Point: 7.1074

>T286818 WP_004966176.1 NZ_LR134117:30363-30761 [Serratia odorifera]
MLKYLLDTNTCIFTIKNKPTLVRERFNLNTSRLCISSVTLMELIYGAEKSQAPERNLAVLEGFIARLDVLNYDAAAAAHS
GQIRAELSRQGLPIGPFDLMIAGHARSQGLIVVTNNTREFERVDGLRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8465.54 Da        Isoelectric Point: 4.5358

>AT286818 WP_004966175.1 NZ_LR134117:30136-30363 [Serratia odorifera]
METTVFLSNRSQAVRLPKAVALPEDVKRVEVIAVGRSRIITPAGEGWDNWFEGENVSADFMTSRDQPPMQEREAF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A447KJV4

References