Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3445401..3446020 Replicon chromosome
Accession NZ_LR134116
Organism Yersinia intermedia strain NCTC11469

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EL015_RS15895 Protein ID WP_002208622.1
Coordinates 3445817..3446020 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9M685
Locus tag EL015_RS15890 Protein ID WP_005182270.1
Coordinates 3445401..3445769 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL015_RS15860 3441032..3441304 + 273 WP_032905607.1 type B 50S ribosomal protein L31 -
EL015_RS15865 3441307..3441450 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EL015_RS15870 3441617..3442495 - 879 WP_005182278.1 metal ABC transporter substrate-binding protein -
EL015_RS15875 3442524..3443381 - 858 WP_032905605.1 metal ABC transporter permease -
EL015_RS15880 3443378..3444115 - 738 WP_050073470.1 ABC transporter ATP-binding protein -
EL015_RS15885 3444889..3445242 + 354 WP_032905603.1 hypothetical protein -
EL015_RS15890 3445401..3445769 + 369 WP_005182270.1 Hha toxicity modulator TomB Antitoxin
EL015_RS15895 3445817..3446020 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EL015_RS15905 3446949..3447254 + 306 WP_186004081.1 MGMT family protein -
EL015_RS15910 3447345..3447899 - 555 WP_005182263.1 YbaY family lipoprotein -
EL015_RS15915 3448158..3449018 + 861 WP_005182259.1 acyl-CoA thioesterase II -
EL015_RS15920 3449098..3450387 - 1290 WP_032905738.1 ammonium transporter AmtB -
EL015_RS15925 3450427..3450765 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T286815 WP_002208622.1 NZ_LR134116:3445817-3446020 [Yersinia intermedia]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14222.93 Da        Isoelectric Point: 4.4314

>AT286815 WP_005182270.1 NZ_LR134116:3445401-3445769 [Yersinia intermedia]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYTCTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M685

References