Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2253648..2254638 Replicon chromosome
Accession NZ_LR134116
Organism Yersinia intermedia strain NCTC11469

Toxin (Protein)


Gene name - Uniprot ID A0A0T9M4G2
Locus tag EL015_RS10320 Protein ID WP_005184404.1
Coordinates 2253648..2254106 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9M4Z0
Locus tag EL015_RS10325 Protein ID WP_005184401.1
Coordinates 2254192..2254638 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL015_RS10290 2249428..2250093 + 666 WP_005184417.1 phage shock protein PspA -
EL015_RS10295 2250237..2250464 + 228 WP_032906081.1 envelope stress response membrane protein PspB -
EL015_RS10300 2250464..2250838 + 375 WP_005184415.1 envelope stress response membrane protein PspC -
EL015_RS10305 2250947..2251186 + 240 WP_005184410.1 phage shock protein PspD -
EL015_RS10310 2251167..2252564 + 1398 WP_032906079.1 YcjX family protein -
EL015_RS10315 2252561..2253622 + 1062 WP_032906077.1 YcjF family protein -
EL015_RS10320 2253648..2254106 - 459 WP_005184404.1 RES family NAD+ phosphorylase Toxin
EL015_RS10325 2254192..2254638 - 447 WP_005184401.1 DUF2384 domain-containing protein Antitoxin
EL015_RS10330 2254956..2256533 + 1578 WP_005184399.1 transcriptional regulator TyrR -
EL015_RS10335 2256646..2257149 - 504 WP_005184397.1 thiol peroxidase -
EL015_RS10340 2257303..2258274 + 972 WP_032906075.1 L-Ala-D/L-Glu epimerase -
EL015_RS10345 2258271..2258978 - 708 WP_032906074.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17201.65 Da        Isoelectric Point: 4.8938

>T286814 WP_005184404.1 NZ_LR134116:c2254106-2253648 [Yersinia intermedia]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALSFAFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16256.70 Da        Isoelectric Point: 9.1234

>AT286814 WP_005184401.1 NZ_LR134116:c2254638-2254192 [Yersinia intermedia]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9M4G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M4Z0

References